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Resident in Internal Medicine.
Acta Biomed. 2020 Nov 10;92(1):e2021025. doi: 10.23750/abm.v92i1.10738.
Coronavirus disease (COVID 19) has involved millions of people all over the world. Tuberculosis (TB) continues to affect millions of people every year with high mortality. There is limited literature on the occurrence of COVID 19 in patients with TB. We reviewed the available data on various clinical details, management, and outcome among patients with COVID-19 and TB. 8 studies reported a total of 80 patients with this coinfection. These patients were reported from ten different countries, with Italy reporting the largest number of cases. Migrant, males constituted a major proportion of cases. Most reported patients were symptomatic. Fever, dry cough, and dyspnea were the most commonly reported symptoms. Bilateral ground glass opacities were more common in COVID 19 infection and cavitary lesions were more common in patients with TB. Most reported TB patients had been found to have mycobacterium tuberculosis from sputum culture in the background of pulmonary TB. Most patients of TB were treated with multidrug regimen antitubercular therapy. In all 8 studies, COVID 19 was treated as per the local protocol. Mortality was reported in more than 10% of patients. Mortality was higher in elderly patients (> 70 years) and amongst patient with multiple medical comorbidities.
冠状病毒病（COVID-19）已影响全球数百万人。结核病（TB）每年仍有数百万人死亡。关于 COVID-19 在结核病患者中的发生情况，文献有限。我们回顾了 COVID-19 和 TB 共感染患者的各种临床细节、治疗和结局的现有数据。8 项研究共报告了 80 例此类共感染患者。这些患者来自十个不同的国家，意大利报告的病例最多。移民、男性构成了大多数病例。大多数报告的患者有症状。发烧、干咳和呼吸困难是最常见的症状。COVID-19 感染中更常见双侧磨玻璃影，而空洞病变在结核病患者中更常见。大多数报告的结核病患者在肺结核的背景下从痰液培养中发现结核分枝杆菌。大多数结核病患者接受了多药方案抗结核治疗。在所有 8 项研究中，COVID-19 均按照当地方案进行治疗。超过 10%的患者报告死亡。在老年患者（>70 岁）和患有多种合并症的患者中，死亡率更高。
