Pak J Biol Sci. 2021 Jan;24(1):139-145. doi: 10.3923/pjbs.2021.139.145.
Haramonting (Rhodomyrtus tomentosa) is an alternative herb to improve health because it has many biological activities and antioxidant. HSP-70 levels as biomarkers of preeclampsia affected the anti-apoptosis of damaged cells in the placenta. This study aimed to evaluate the role of HSP-70 expressions by investigating whether effect haramonting leaves in PE rats.
The study design was control (C): pregnant rats without treatment, PE: Preeclamptic rats, PE+E: PE rats were given 1 mL EVOO kg-1 b.wt./day orally (pregnancy 13-19), PE+H: PE rats were given nano herbal haramonting 100 mg kg-1 b.wt. (pregnancy 13-19 days). PE+E+H: PE rats were given EVOO 0.5 mL kg-1 b.wt. and nano herbal haramonting 50 mg kg-1 b.wt. (pregnancy 13-19 day). Surgery was performed by taking blood from the heart for the SGOT/SGPT parameters, creatinine and HSP70.
A significant difference was observed in all groups with the value p<0.0001 and HSP-70 Expressions affect in preeclamptic rats after given this herbal. The value of SGOT, SGPT and creatinine can affect preeclamptic rats and can be as a biomarker of preeclampsia. A significant difference also in fetus weight (p<0.01) but an insignificant difference in placental weight (p>0.05).
These findings indicate that Nano herbal haramonting and EVOO possess antioxidative effects and a promising drug for the future in the treatment of preeclampsia.
悬钩子（Rhodomyrtus tomentosa）是一种替代草药，可以改善健康，因为它具有许多生物活性和抗氧化作用。HSP-70 水平作为子痫前期的生物标志物，影响胎盘受损细胞的抗凋亡作用。本研究旨在通过研究悬钩子叶对 PE 大鼠的影响来评估 HSP-70 表达的作用。
研究设计为对照组（C）：未经治疗的妊娠大鼠；PE 组：子痫前期大鼠；PE+E 组：PE 大鼠给予 1 mL EVOO kg-1 b.wt./天口服（妊娠 13-19 天）；PE+H 组：PE 大鼠给予纳米草药悬钩子 100 mg kg-1 b.wt.（妊娠 13-19 天）。PE+E+H 组：PE 大鼠给予 EVOO 0.5 mL kg-1 b.wt.和纳米草药悬钩子 50 mg kg-1 b.wt.（妊娠 13-19 天）。通过从心脏取血进行 SGOT/SGPT 参数、肌酐和 HSP70 手术。
所有组均观察到显著差异，p<0.0001，HSP-70 表达影响给予这种草药后的子痫前期大鼠。SGOT、SGPT 和肌酐的值会影响子痫前期大鼠，可以作为子痫前期的生物标志物。胎鼠体重也有显著差异（p<0.01），但胎盘重量无显著差异（p>0.05）。
这些发现表明，纳米草药悬钩子和 EVOO 具有抗氧化作用，是未来治疗子痫前期的有前途的药物。
