Situmorang Putri Cahaya, Ilyas Syafruddin, Hutahaean Salomo, Rosidah Rosidah
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan 20155, Indonesia.
Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.
Open Access Maced J Med Sci. 2019 Jul 14;7(14):2226-2231. doi: 10.3889/oamjms.2019.651. eCollection 2019 Jul 30.
Andaliman () is a spice traditional Northen Sumatera, Indonesia and these fruits contain alkaloids, steroids and terpenoids. Extra Virgin Olive Oil (EVOO) contains antioxidants. Combination of this plant have activities to reduce preeclampsia.
To know the safety of the combination of nano herbal andaliman and Extra virgin olive oil (EVOO) on preeclampsia patients' liver.
Pregnant rats were made to have preeclampsia with 3 ml of NaCl 6% injections. This research consists of 5 groups: K- (negative control): normal pregnant rats, K+: preeclampsia rats; P1: PE rats were given nano herbal andaliman 1 ml EVOO / day / 20 gBW from the 13th to the 19th day of pregnancy, P2: PE rats were given nano herbal andaliman 100 mg/day / 200 gBW from the 13th to the 19th day of pregnancy, P3: PE was given the combination of 1 ml EVOO/day / 200 gBW and andaliman nano herbal 100 mg/day/200 gBW on the 13th day of pregnancy to the 19th day given orally. Then on the 20th day of pregnancy, the subjects were dissected.
There were significant differences (p < 0.05) on the value of SGOT, SGPT, and the average damage of the hepatocyte cells except parenchymatous degeneration after being given the nano herbal andaliman and EVOO. The compared mean of normal hepatocytes cell, hydropic degeneration and necrosis value between all groups were p < 0.05 and p < 0.01 compared to (K-). The non-significant difference was found in the mean of parenchymatous degeneration between the groups (p = 0.058).
The combination of nano herbal andaliman () and EVOO affected the level of necrosis in hepatocyte cells on preeclampsia rats.
山柰（Andaliman）是印度尼西亚北苏门答腊的一种传统香料，这些果实含有生物碱、类固醇和萜类化合物。特级初榨橄榄油（EVOO）含有抗氧化剂。这种植物的组合具有降低先兆子痫的作用。
了解纳米草药山柰与特级初榨橄榄油（EVOO）组合对先兆子痫患者肝脏的安全性。
通过注射3毫升6%的氯化钠使怀孕大鼠患先兆子痫。本研究分为5组：K-（阴性对照）：正常怀孕大鼠；K+：先兆子痫大鼠；P1：从怀孕第13天到第19天，给先兆子痫大鼠每天每20克体重灌胃1毫升EVOO和纳米草药山柰；P2：从怀孕第13天到第19天，给先兆子痫大鼠每天每200克体重灌胃100毫克纳米草药山柰；P3：从怀孕第13天到第19天，给先兆子痫大鼠每天每200克体重口服1毫升EVOO和100毫克纳米草药山柰。然后在怀孕第20天，对实验对象进行解剖。
给予纳米草药山柰和EVOO后，除实质变性外，血清谷草转氨酶（SGOT）、血清谷丙转氨酶（SGPT）值及肝细胞平均损伤程度存在显著差异（p<0.05）。与（K-）组相比，所有组正常肝细胞、水样变性和坏死值的比较均值p<0.05和p<0.01。各组间实质变性均值无显著差异（p=0.058）。
纳米草药山柰与EVOO的组合影响先兆子痫大鼠肝细胞的坏死水平。
