Wang Shuqing, Wang Haiping, Liu Xuejun, Yan Wenjing, Wang Minghui, Zhao Renliang
Department of Neurology, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266003, China.
Department of Radiology, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266003, China.
Acta Neurol Belg. 2023 Feb;123(1):99-105. doi: 10.1007/s13760-021-01639-9. Epub 2021 Mar 8.
To evaluate the spontaneous neuronal activities and the changes of brain functional network in patients with vestibular migraine (VM). Three groups including18 patients with VM, 21 patients with migraine without aura (MWoA) and 21 healthy controls (HCs) underwent the scanning of the resting-state fMRI. Covariance analysis and bonferroni multiple comparisons were used to obtain brain regions with significant differences in amplitude of low-frequency fluctuation (ALFF) values. Furthermore, the brain regions with the most significant differences of ALFF values were recognized as a region of interest (ROI) and functional connectivity (FC) analysis was performed in these regions. (1) ALFF: Compared with HCs, patients with VM showed significantly lower ALFF in the right putamen (P < 0.05), and significantly higher ALFF in the right lingual gyrus (P < 0.05). In addition, compared with MWoA patients, patients with VM showed significantly higher ALFF in the right lingual gyrus (P < 0.05). (2) Compared with HCs, VM patients showed significantly higher FC among the cerebellum, the left dorsolateral superior frontal gyrus and the right putamen (P < 0.05) but significantly lower FC among the left median cingulate, paracingulate gyri and the right putamen (P < 0.05). Compared with MWoA patients, VM patients showed significantly higher FC between the cerebellum and the right putamen (P < 0.05) but significantly lower FC among the left median cingulate, paracingulate gyri and the right putamen (P < 0.05). There are functional abnormalities in nociceptive, vestibular and visual cortex regions in patients with VM during the interictal period.
评估前庭性偏头痛（VM）患者的自发神经元活动及脑功能网络变化。18例VM患者、21例无先兆偏头痛（MWoA）患者和21名健康对照者（HCs）三组接受静息态功能磁共振成像扫描。采用协方差分析和Bonferroni多重比较来获取低频波动幅度（ALFF）值有显著差异的脑区。此外，将ALFF值差异最显著的脑区确定为感兴趣区（ROI），并在这些区域进行功能连接（FC）分析。（1）ALFF：与HCs相比，VM患者右侧壳核的ALFF显著降低（P<0.05），右侧舌回的ALFF显著升高（P<0.05）。此外，与MWoA患者相比，VM患者右侧舌回的ALFF显著升高（P<0.05）。（2）与HCs相比，VM患者小脑、左侧背外侧额上回和右侧壳核之间的FC显著升高（P<0.05），但左侧中央扣带回、旁扣带回和右侧壳核之间的FC显著降低（P<0.05）。与MWoA患者相比，VM患者小脑和右侧壳核之间的FC显著升高（P<0.05），但左侧中央扣带回、旁扣带回和右侧壳核之间的FC显著降低（P<0.05）。VM患者发作间期在伤害性、前庭和视觉皮层区域存在功能异常。
