Department of Radiology, The Affiliated Jiangning Hospital with Nanjing Medical University, No.169, Hushan Road, 211100, Nanjing, Jiangsu, China.
Department of Neurology, The Affiliated Jiangning Hospital with Nanjing Medical University, No.169, Hushan Road, 211100, Nanjing, Jiangsu, China.
J Headache Pain. 2021 May 21;22(1):40. doi: 10.1186/s10194-021-01259-x.
Migraine is a common neurological disease that is often accompanied by psychiatric comorbidities. However, the relationship between abnormal brain function and psychiatric comorbidities in migraine patients remains largely unclear. Therefore, the present study sought to explore the correlations between the resting-state functional deficits and psychiatric comorbidities in migraine without aura (MwoA) patients.
Resting-state functional magnetic resonance images were obtained. In addition, the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values were obtained. Thereafter regional abnormalities in MwoA patients with and without anxiety (MwoA-A and MwoA-OA) were chosen as seeds to conduct functional connectivity (FC) analysis.
Compared to the healthy controls (HCs), the MwoA-A and MwoA-OA patients had abnormal ALFF and ReHo values in the right lingual gyrus (LG). They also had abnormal FC of the right LG with the ipsilateral superior frontal gyrus (SFG) and middle cingulate cortex (MCC). Additionally, the MwoA-A patients showed higher ReHo values in the left posterior intraparietal sulcus (pIPS) and abnormal FC of the right LG with ipsilateral pIPS and primary visual cortex, compared to the MwoA-OA patients. Moreover, the MwoA-OA patients showed an increase in the FC with the right posterior cingulate cortex/precuneus (PCC/PCUN), left middle frontal gyrus (MFG) and left inferior temporal gyrus (ITG) relative to the HCs. Furthermore, the ALFF values of the right LG positively were correlated with anxiety scores in MwoA-A patients. The abnormal LG-related FCs with the PCC/PCUN, MFG and ITG were negatively associated with the frequency of headaches in MwoA-OA patients.
This study identified abnormal visual FC along with other core networks differentiating anxiety comorbidity from MwoA. This may therefore enhance the understanding of the neuropsychological basis of psychiatric comorbidities and provide novel insights that may help in the discovery of new marks or even treatment targets.
偏头痛是一种常见的神经系统疾病，常伴有精神共病。然而，偏头痛患者异常脑功能与精神共病之间的关系仍不清楚。因此，本研究旨在探讨无先兆偏头痛（MwoA）患者静息态功能缺陷与精神共病之间的相关性。
采集静息态功能磁共振成像数据，获得低频振幅（ALFF）和局部一致性（ReHo）值。然后选择有无焦虑的 MwoA 患者（MwoA-A 和 MwoA-OA）的脑区异常作为种子点进行功能连接（FC）分析。
与健康对照组（HCs）相比，MwoA-A 和 MwoA-OA 患者右侧舌回（LG）的 ALFF 和 ReHo 值异常，右侧 LG 与同侧额上回（SFG）和扣带回中部（MCC）的 FC 异常。此外，与 MwoA-OA 患者相比，MwoA-A 患者左侧顶内沟后回（pIPS）的 ReHo 值较高，右侧 LG 与同侧 pIPS 和初级视觉皮层的 FC 异常。而且，MwoA-OA 患者右侧后扣带回/楔前叶（PCC/PCUN）、左侧额中回（MFG）和左侧颞下回（ITG）与 MwoA-A 患者相比，FC 增加。此外，MwoA-A 患者右侧 LG 的 ALFF 值与焦虑评分呈正相关。与 PCC/PCUN、MFG 和 ITG 的异常 LG 相关 FC 与 MwoA-OA 患者头痛频率呈负相关。
本研究发现了区分焦虑共病与 MwoA 的异常视觉 FC 以及其他核心网络。这可能有助于深入了解精神共病的神经心理学基础，并提供新的见解，有助于发现新的标志物甚至治疗靶点。
