Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.
NMR Biomed. 2013 Sep;26(9):1051-8. doi: 10.1002/nbm.2917. Epub 2013 Jan 24.
Although previous resting-state studies have reported abnormal functional cerebral changes in patients with migraine without aura (MwoA), few have focused on alterations in both regional spontaneous neuronal activity and corresponding brain circuits in MwoA patients during rest. Eighteen MwoA patients and 18 age- and gender-matched healthy controls (HC) were recruited in the current study. Baseline cerebral alterations were investigated using amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) analyses. Compared with HC, MwoA patients showed decreased ALFF values in the left rostral anterior cingulate cortex (rACC) and bilateral prefrontal cortex (PFC) as well as increased ALFF values in the right thalamus. FC analysis also revealed abnormal FCs associated with these ROIs. In addition, ALFF values of the left rACC correlated with duration of disease in MwoA. Our findings could lead to a better understanding of intrinsic functional architecture of baseline brain activity in MwoA, providing both regional and brain circuit spontaneous neuronal activity properties.
尽管先前的静息态研究已经报道了无先兆偏头痛（MwoA）患者大脑功能的异常变化，但很少有研究关注 MwoA 患者在静息状态下局部自发性神经元活动和相应脑区回路的变化。本研究纳入了 18 名 MwoA 患者和 18 名年龄和性别匹配的健康对照者（HC）。使用低频振幅（ALFF）和基于感兴趣区（ROI）的功能连接（FC）分析来研究基线时的脑改变。与 HC 相比，MwoA 患者左额前皮质（rACC）和双侧前额叶皮质（PFC）的 ALFF 值降低，右侧丘脑的 ALFF 值升高。FC 分析还揭示了与这些 ROI 相关的异常 FC。此外，MwoA 患者左 rACC 的 ALFF 值与疾病持续时间相关。我们的发现可以更好地理解 MwoA 患者静息态脑活动的固有功能结构，提供局部和脑区自发神经元活动的特性。
