Department of Agroenvironmental Chemistry and Plant Nutrition, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Praha 6 - Suchdol, Czech Republic.
Fitoterapia. 2021 Jun;151:104845. doi: 10.1016/j.fitote.2021.104845. Epub 2021 Mar 5.
The importance of natural raw materials has grown recently because of their ready availability, renewable nature, biocompatibility and controllable degradability. One such group of plant-derived substances includes the triterpenoid acids, terpenic compounds consisting of six isoprene units, a carboxyl group and other functional groups producing various isomers. Most can be easily extracted from different parts of the plant and modified successfully. By themselves or as aglycones (genins) of triterpene saponins, they have potentially useful pharmaceutical activity. This review focuses on the supramolecular properties of triterpenoid acids with regard to their subsequent use as biocompatible nanocarriers. The review also considers the current list of pentacyclic triterpene acids for which molecular self-assembly has been confirmed without the need for structural modification.
由于其易得性、可再生性、生物相容性和可控降解性，天然原料的重要性最近有所增加。植物衍生物质的一类包括三萜酸，萜类化合物由六个异戊二烯单元、一个羧基和产生各种异构体的其他官能团组成。大多数萜类酸很容易从植物的不同部位提取出来，并能成功地进行修饰。它们本身或作为三萜皂苷的苷元，具有潜在的有用的药物活性。本文综述了三萜酸的超分子性质，以及它们随后作为生物相容的纳米载体的应用。本文还考虑了目前已确认无需结构修饰即可进行分子自组装的五碳环三萜酸的清单。
