关于“A. Grylls、K. Seidler、J. Neil，微生物群与高血压之间的联系：关注内皮功能障碍和血管炎症中的LPS/TLR4途径以及益生菌的治疗意义”的通信 - Suppr

Correspondence on 'A. Grylls, K. Seidler, J. Neil, Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics'.

作者信息

Suadoni Marco Tullio

机构信息

Cambridgeshire Community Services NHS Trust Luton Adults Health Services Cambridgeshire Community Services NHS Trust The Poynt Luton LU4 0LA United Kingdom.

出版信息

Biomed Pharmacother. 2021 Jun;138:111432. doi: 10.1016/j.biopha.2021.111432. Epub 2021 Mar 6.

DOI:10.1016/j.biopha.2021.111432

PMID:33684692

Abstract

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Correspondence on 'A. Grylls, K. Seidler, J. Neil, Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics'.关于“A. Grylls、K. Seidler、J. Neil，微生物群与高血压之间的联系：关注内皮功能障碍和血管炎症中的LPS/TLR4途径以及益生菌的治疗意义”的通信

Biomed Pharmacother. 2021 Jun;138:111432. doi: 10.1016/j.biopha.2021.111432. Epub 2021 Mar 6.

Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics.肠道菌群与高血压的关系：聚焦于内皮功能障碍和血管炎症中的 LPS/TLR4 通路，以及益生菌的治疗意义。

Biomed Pharmacother. 2021 May;137:111334. doi: 10.1016/j.biopha.2021.111334. Epub 2021 Feb 5.

Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia.益生菌可能通过恢复肠道微生物群落结构和改善肠道内毒素血症来延缓非酒精性脂肪性肝病的进展。

Sci Rep. 2017 Mar 28;7:45176. doi: 10.1038/srep45176.

Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently.丹皮酚通过同时但独立抑制 BMP4 和 TLR4 信号通路来减轻 LPS 诱导的内皮功能障碍和细胞凋亡。

J Pharmacol Exp Ther. 2018 Mar;364(3):420-432. doi: 10.1124/jpet.117.245217. Epub 2017 Dec 19.

Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells.TLR4与PPARγ的相互作用，依赖于AMPK信号通路，有助于王不留行籽Hypaphorine对内皮细胞的抗炎作用。

Cell Physiol Biochem. 2017;42(3):1227-1239. doi: 10.1159/000478920. Epub 2017 Jul 3.

Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway.Hypaphorine通过依赖PI3K/Akt/mTOR信号通路调控TLR4和PPAR-γ减轻脂多糖诱导的内皮炎症。

Int J Mol Sci. 2017 Apr 17;18(4):844. doi: 10.3390/ijms18040844.

Probiotic consumption during puberty mitigates LPS-induced immune responses and protects against stress-induced depression- and anxiety-like behaviors in adulthood in a sex-specific manner.青春期摄入益生菌可减轻 LPS 诱导的免疫反应，并以性别特异性方式预防成年期应激诱导的抑郁和焦虑样行为。

Brain Behav Immun. 2019 Oct;81:198-212. doi: 10.1016/j.bbi.2019.06.016. Epub 2019 Jun 15.

LPS induces inflammatory responses in human aortic vascular smooth muscle cells via Toll-like receptor 4 expression and nitric oxide production.脂多糖通过Toll样受体4表达和一氧化氮生成，诱导人主动脉血管平滑肌细胞发生炎症反应。

Immunol Lett. 2008 Oct 30;120(1-2):57-64. doi: 10.1016/j.imlet.2008.07.002. Epub 2008 Jul 31.

LPS induces CXCL16 expression in HUVECs through the miR-146a-mediated TLR4 pathway.LPS 通过 miR-146a 介导的 TLR4 通路诱导 HUVECs 表达 CXCL16。

Int Immunopharmacol. 2019 Apr;69:143-149. doi: 10.1016/j.intimp.2019.01.011. Epub 2019 Jan 30.

Anti-Inflammatory Activity of Adenosine 5'-Trisphosphate in Lipopolysaccharide-Stimulated Human Umbilical Vein Endothelial Cells Through Negative Regulation of Toll-Like Receptor MyD88 Signaling.三磷酸腺苷通过负调控 Toll 样受体 MyD88 信号通路对脂多糖刺激的人脐静脉内皮细胞的抗炎活性。

DNA Cell Biol. 2019 Dec;38(12):1557-1563. doi: 10.1089/dna.2019.4773. Epub 2019 Oct 3.

引用本文的文献

Probiotics: functional food ingredients with the potential to reduce hypertension.益生菌：具有降低高血压潜力的功能性食品成分。

Front Cell Infect Microbiol. 2023 Jul 3;13:1220877. doi: 10.3389/fcimb.2023.1220877. eCollection 2023.

Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway.研究益生菌和益生元通过调节 TLR4/NF-kB 信号通路对卵清蛋白-脂多糖诱导的过敏性哮喘炎症和肺炎的治疗作用。

J Transl Med. 2022 Mar 16;20(1):130. doi: 10.1186/s12967-022-03337-3.

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Correspondence on 'A. Grylls, K. Seidler, J. Neil, Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics'.

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