State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Science, Jinan, China.
School of Bioengineering, Qilu University of Technology, Shandong Academy of Science, Jinan, China.
Front Cell Infect Microbiol. 2023 Jul 3;13:1220877. doi: 10.3389/fcimb.2023.1220877. eCollection 2023.
Hypertension is an increasingly pressing public health concern across the globe. It can be triggered by a variety of factors such as age and diet, as well as the stress of modern life. The traditional treatment of hypertension includes calcium ion blockers, angiotensin II receptor inhibitors and β-receptor blockers, but these drugs have at least some side effects. Recent studies have revealed that intestinal flora plays a vital role in maintaining and promoting human health. This is due to the type and amount of probiotics present in the flora. Probiotics can reduce hypertension symptoms through four mechanisms: regulating vascular oxidative stress, producing short-chain fatty acids, restoring endothelial cell function, and reducing inflammation. It has been reported that certain functional foods, using probiotics as their raw material, can modify the composition of intestinal flora, thus regulating hypertension symptoms. Consequently, utilizing the probiotic function of probiotics in conjunction with the properties of functional foods to treat hypertension is a novel, side-effect-free treatment method. This study seeks to summarize the various factors that contribute to hypertension, the mechanism of probiotics in mitigating hypertension, and the fermented functional foods with probiotic strains, in order to provide a basis for the development of functional foods which utilize probiotics as their raw material and may have the potential to reduce hypertension.
高血压是全球范围内日益紧迫的公共卫生问题。它可能由多种因素引起，如年龄、饮食以及现代生活的压力。高血压的传统治疗方法包括钙离子通道阻滞剂、血管紧张素 II 受体抑制剂和β受体阻滞剂，但这些药物至少有一些副作用。最近的研究表明，肠道菌群在维持和促进人类健康方面起着至关重要的作用。这是由于菌群中存在的益生菌的种类和数量。益生菌可以通过四种机制来减轻高血压症状：调节血管氧化应激、产生短链脂肪酸、恢复内皮细胞功能和减少炎症。据报道，某些功能性食品以益生菌为原料，可以改变肠道菌群的组成，从而调节高血压症状。因此，利用益生菌的功能结合功能性食品的特性来治疗高血压是一种新颖的、无副作用的治疗方法。本研究旨在总结导致高血压的各种因素、益生菌缓解高血压的机制以及含有益生菌菌株的发酵功能性食品，为利用益生菌作为原料开发功能性食品提供依据，这些功能性食品可能具有降低高血压的潜力。
