Okabe Y, Sakata T, Fujimoto K, Kurata K, Yoshimatsu H, Ueda K
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Proc Soc Exp Biol Med. 1988 May;188(1):23-9. doi: 10.3181/00379727-188-42701.
The present study examined and compared the effects of N-acetylglucosamine and 1-deoxy-N-acetylglucosamine on feeding behavior with those of glucosamine and 1-deoxyglucosamine. Infusion of 12 mu mole N-acetylglucosamine and 24 mu mole 1-deoxy-N-acetylglucosamine into the rat third cerebroventricle did not affect the feeding behavior. However, oral administration of 1200 mumol N-acetylglucosamine elicited feeding and 2400 mumol 1-deoxy-N-acetylglucosamine markedly suppressed feeding. These effects were abolished by truncal vagotomy. Both glucosamine and 1-deoxyglucosamine affected feeding by intra-third cerebroventricular and oral administration. These findings indicate that N-acetyl amino sugars modulate feeding behavior peripherally through the vagal afferent nerve.
本研究检测并比较了N-乙酰葡糖胺和1-脱氧-N-乙酰葡糖胺对摄食行为的影响，并与葡糖胺和1-脱氧葡糖胺的影响进行了对比。向大鼠第三脑室注入12微摩尔N-乙酰葡糖胺和24微摩尔1-脱氧-N-乙酰葡糖胺并未影响摄食行为。然而，口服1200微摩尔N-乙酰葡糖胺会引发摄食，而2400微摩尔1-脱氧-N-乙酰葡糖胺则显著抑制摄食。这些作用通过切断迷走神经而消除。葡糖胺和1-脱氧葡糖胺通过第三脑室内注射和口服给药均会影响摄食。这些发现表明，N-乙酰氨基糖通过迷走传入神经在外周调节摄食行为。
