Dufour P, Gendre P
Department of Pharmacology, University of Bordeaux II, School of Pharmacy, France.
Pharmacology. 1988;36 Suppl 1:194-202. doi: 10.1159/000138440.
Sennosides and related compounds are presumed to be severe cell poisons after prolonged ingestion. Some histological and ultrastructural studies in animals and man with such laxative misuse have revealed myenteric plexus and colonic epithelium injuries; but others have failed to point out identical data. In a first histological and ultrastructural study in mouse, we were unable to find any intestinal mucosa injury after long-term sennoside ingestion. In a second long-term experiment, we compared the effects of sennosides and 1,8-dihydroxyanthraquinone (synthetic anthracene derivative) on the mouse jejunum and colon. Electron microscopic observations showed nervous myenteric plexus abnormalities only in 1,8-dihydroxyanthraquinone-treated animals. These results suggest that sennosides have a good intestinal mucosa tolerance as opposed to aglycosidic-related compounds.
长期摄入后，番泻苷及相关化合物被认为是严重的细胞毒素。一些针对滥用此类泻药的动物和人类进行的组织学和超微结构研究显示，肌间神经丛和结肠上皮有损伤；但其他研究未能指出相同的数据。在第一项针对小鼠的组织学和超微结构研究中，我们未能发现长期摄入番泻苷后有任何肠黏膜损伤。在第二项长期实验中，我们比较了番泻苷和1,8 - 二羟基蒽醌（合成蒽衍生物）对小鼠空肠和结肠的影响。电子显微镜观察显示，仅在接受1,8 - 二羟基蒽醌治疗的动物中出现了肌间神经丛异常。这些结果表明，与糖苷配基相关化合物相比，番泻苷对肠黏膜具有良好的耐受性。
