Candemir Mustafa, Kiziltunç Emrullah, Nurkoç Serdar, Şahinarslan Asife
Department of Cardiology, 64001Faculty of Medicine, Gazi University, Ankara, Turkey.
Yozgat City Hospital, Department of Cardiology, Yozgat, Turkey.
Angiology. 2021 Jul;72(6):575-581. doi: 10.1177/0003319720987743. Epub 2021 Mar 9.
Systemic immune-inflammation index (SII; platelet count × neutrophil-to-lymphocyte ratio), a novel marker, predicts adverse clinical outcomes in coronary artery diseases (CAD). We hypothesized that SII could provide more valuable information in assessing the severity of CAD than ratios obtained from other white blood cell subtypes. Patients (n = 669) who underwent coronary angiography were analyzed in this retrospective study. We analyzed the relation between the SII and the angiographic severity of CAD. The severity of coronary atherosclerosis was determined by the SYNTAX score (SxS). Patients with CAD were divided into 3 groups according to the SxS. Multivariate logistic analysis was used to assess risk factors of CAD. In multivariate logistic regression analysis, the SII (odds ratio: 1.004; 95% CI: 1.001-1.007; = .015) was an independent predictor of high SxS. Additionally, there was a positive correlation between SII and SxS (Rho: 0.630, ≤ .001). In the receiver-operating characteristic curve analysis, SII with an optimal cutoff value of 750 × 10 predicted the severe coronary lesion with a sensitivity of 86.2% and specificity of 87.3%. The SII, an inexpensive and easily measurable laboratory variable, was significantly associated with the severity of CAD and high SxS in patients with stable angina pectoris.
全身免疫炎症指数（SII；血小板计数×中性粒细胞与淋巴细胞比值）作为一种新型标志物，可预测冠状动脉疾病（CAD）的不良临床结局。我们假设，与从其他白细胞亚型得出的比值相比，SII在评估CAD严重程度方面能提供更有价值的信息。本回顾性研究分析了669例接受冠状动脉造影的患者。我们分析了SII与CAD血管造影严重程度之间的关系。冠状动脉粥样硬化的严重程度由SYNTAX评分（SxS）确定。根据SxS将CAD患者分为3组。采用多因素logistic分析评估CAD的危险因素。在多因素logistic回归分析中，SII（比值比：1.004；95%可信区间：1.001 - 1.007；P = 0.015）是高SxS的独立预测因子。此外，SII与SxS之间存在正相关（Rho：0.630，P≤0.001）。在受试者工作特征曲线分析中，最佳截断值为750×10的SII预测严重冠状动脉病变的敏感度为86.2%，特异度为87.3%。SII作为一种廉价且易于测量的实验室指标，与稳定型心绞痛患者的CAD严重程度和高SxS显著相关。
