University Eye Clinic, San Giuseppe Hospital, IRCCS Multimedica, Milan, Italy.
Department of Clinical Science and Community Health, University of Milan, Milan, Italy.
Eur J Ophthalmol. 2022 Jan;32(1):327-335. doi: 10.1177/1120672121999997. Epub 2021 Mar 8.
We compared the efficacy and safety of trabeculectomy and phacotrabeculectomy in patients with glaucoma.
We retrospectively analyzed consecutive patients who underwent trabeculectomy or phacotrabeculectomy. Patients in the trabeculectomy group were pseudophakic. We established three different intraocular pressure (IOP) thresholds (A: <21 mmHg, B: <18 mmHg, and C: <15 mmHg) to measure complete (without medication) and qualified (with medication) success. Success criteria were analyzed through Kaplan-Meier survival curves.
Sixty-seven eyes were included (40 trabeculectomy, 27 phacotrabeculectomy). The mean follow-up period was 25.70 ± 14.439 months. The baseline characteristics were similar between the groups. The complete and qualified success rates according to criterion C were significantly higher in the trabeculectomy group ( = 0.033, = 0.021, respectively); however, there was a trend toward a higher success rate for all criteria in favor of trabeculectomy. Bleb needling was more frequent in the phacotrabeculectomy group. The mean IOP significantly decreased from 26.46 ± 7.07 to 12.27 ± 4.06 at 12 months ( < 0.001). The final mean IOP was significantly lower in the trabeculectomy than in the phacotrabeculectomy group (10.95 ± 3.08 vs 13.00 ± 4.56, = 0.0003).
In pseudophakic eyes, trabeculectomy alone achieves a higher success rate, lower mean IOP, and less frequent bleb needlings. More frequent follow-up and prolonged postoperative use of high-dose topical steroids should be considered in patients undergoing phacotrabeculectomy.
我们比较了青光眼患者小梁切除术和超声乳化白内障吸除术联合小梁切除术的疗效和安全性。
我们回顾性分析了连续接受小梁切除术或超声乳化白内障吸除术联合小梁切除术的患者。小梁切除术组的患者为无晶状体眼。我们建立了三个不同的眼压(IOP)阈值(A:<21mmHg,B:<18mmHg,C:<15mmHg)来衡量完全(无需药物)和合格(需药物)的成功率。通过 Kaplan-Meier 生存曲线分析成功标准。
共纳入 67 只眼(40 只小梁切除术,27 只超声乳化白内障吸除术联合小梁切除术)。平均随访时间为 25.70±14.439 个月。两组基线特征相似。根据标准 C,小梁切除术组的完全和合格成功率明显更高(=0.033,=0.021);然而,所有标准均倾向于小梁切除术组的成功率更高。超声乳化白内障吸除术联合小梁切除术组的眼内压需要频繁针刺。12 个月时,眼压从 26.46±7.07mmHg 显著下降至 12.27±4.06mmHg(<0.001)。小梁切除术组的最终平均眼压明显低于超声乳化白内障吸除术联合小梁切除术组(10.95±3.08mmHg 比 13.00±4.56mmHg,=0.0003)。
在无晶状体眼中,单独行小梁切除术可获得更高的成功率、更低的平均眼压和更少的眼内压需要频繁针刺。行超声乳化白内障吸除术联合小梁切除术的患者应考虑更频繁的随访和延长术后高剂量局部皮质类固醇的使用。