Merikangas K R, Weissman M M, Prusoff B A, John K
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519.
Psychiatry. 1988 Feb;51(1):48-57. doi: 10.1080/00332747.1988.11024379.
Familial aggregation has been frequently observed among probands with depression, anxiety disorders, and alcoholism (Gershon et al. 1976; Goodwin et al. 1973; Crowe et al. 1983). Because of the familial nature of these disorders, offspring of such probands have been identified to be at high risk for developing these illnesses themselves (Tarter 1983). Information regarding such risk has come from several sources: retrospective studies of patients with psychiatric disorders; studies of children whose parents are being treated for these disorders; and longitudinal follow-up studies of children with symptoms of the disorder.
在患有抑郁症、焦虑症和酗酒症的先证者中,经常观察到家族聚集现象(格申等人,1976年;古德温等人,1973年;克罗等人,1983年)。由于这些疾病具有家族性,已确定这些先证者的后代自身患这些疾病的风险很高(塔尔特,1983年)。关于这种风险的信息来自多个来源:对精神疾病患者的回顾性研究;对父母正在接受这些疾病治疗的儿童的研究;以及对有该疾病症状儿童的纵向随访研究。