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利福霉素衍生物对非结核分枝杆菌的活性，包括对大环内酯类/阿米卡星耐药的临床分离株

Activity of Rifamycin Derivatives against Nontuberculous Mycobacteria, including Macrolide-/Amikacin-Resistant Clinical Isolates.

作者信息

Kim Dae Hun, Kim Su-Young, Huh Hee Jae, Lee Nam Yong, Koh Won-Jung, Jhun Byung Woo

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

出版信息

Antimicrob Agents Chemother. 2023 May 1;65(5). doi: 10.1128/AAC.02611-20. Epub 2021 Mar 8.

DOI:10.1128/AAC.02611-20
PMID:33685889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8092860/
Abstract

We evaluated the activity of rifamycin derivatives, including rifampin, rifapentine, rifaximin, and rifabutin, against clinical nontuberculous mycobacteria (NTM) isolates. Of the rifamycin derivatives, rifabutin showed the lowest MICs against all NTM species, including complex, , and Rifabutin also had effective activity against macrolide- and aminoglycoside-resistant NTM isolates. Rifabutin could be worth considering as a therapeutic option for NTM disease, particularly drug-resistant disease.

摘要

我们评估了利福霉素衍生物，包括利福平、利福喷汀、利福昔明和利福布汀，对临床非结核分枝杆菌（NTM）分离株的活性。在利福霉素衍生物中，利福布汀对所有NTM菌种，包括复合群、 和 ，显示出最低的最低抑菌浓度（MIC）。利福布汀对大环内酯类和氨基糖苷类耐药的NTM分离株也具有有效的活性。利福布汀可能值得作为NTM疾病，特别是耐药疾病的一种治疗选择来考虑。

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本文引用的文献

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In vitro susceptibility of Mycobacterium abscessus complex and feasibility of standardizing treatment regimens.脓肿分枝杆菌复合体的体外药敏试验及标准化治疗方案的可行性。
J Antimicrob Chemother. 2021 Mar 12;76(4):973-978. doi: 10.1093/jac/dkaa520.
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Rifabutin Is Bactericidal against Intracellular and Extracellular Forms of Mycobacterium abscessus.利福布汀对脓肿分枝杆菌的细胞内和细胞外形式均具有杀菌作用。
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Rifabutin Is Active against Mycobacterium abscessus in Mice.利福布汀对小鼠中的脓肿分枝杆菌有效。
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Repositioning rifamycins for Mycobacterium abscessus lung disease.重新定位利福霉素类药物治疗脓肿分枝杆菌肺病。
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