Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Department of Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey, USA.
Antimicrob Agents Chemother. 2020 Jan 27;64(2). doi: 10.1128/AAC.01943-19.
There is no reliable cure for lung disease. Rifampin is not used clinically due to poor potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent against Here, we report that rifabutin is as active as clarithromycin against K21 in NOD.CB17-Prkdc/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with disease.
目前尚无治愈肺病的可靠方法。利福平由于效力不佳，临床上已不再使用。相比之下，我们已经证明，另一种用于治疗结核病的批准利福霉素利福布汀对 具有很强的活性。在这里，我们报告利福布汀对 NOD.CB17-Prkdc/NCrCrl 小鼠中的 具有与克拉霉素相当的活性。这表明利福布汀应该被视为 疾病患者的重新定位候选药物。
