Zhang Rui, Xu Ming, Xie Xiao-Yan
Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-sen University, Guangzhou, China.
Front Oncol. 2021 Feb 23;11:585257. doi: 10.3389/fonc.2021.585257. eCollection 2021.
Reninoma is a rare renal endocrine tumor that can cause secondary hypertension, characterized by hypertension, hypokalemia, high renin and aldosterone with normal aldosterone renin ratio (ARR), and occurs more in young female. Mainstream treatment option is surgery, but is less suitable for small or deep lesions, which makes ablation a promising alternative.
Two young female with typical manifestations of reninoma, including hypertension, hypokalemia, high renin, high aldosterone and normal ARR, were treated successfully with real-time contrast-enhanced ultrasound guided radiofrequency ablation, and contrast-enhanced ultrasound was also performed before and after treatment for diagnosis and postoperative assessment. Afterward, their blood pressure and laboratory tests became normal and remained steady during the follow-up of 32 and 6 months, respectively.
Contrast-enhanced ultrasound guided radiofrequency ablations is a promising alternative for reninoma treatment with comparable safety and efficacy with surgery, and has advantages especially in small or deep lesions.
肾素瘤是一种罕见的肾脏内分泌肿瘤，可导致继发性高血压，其特征为高血压、低钾血症、高肾素和醛固酮，醛固酮肾素比值（ARR）正常，多见于年轻女性。主流治疗方法是手术，但对于小病灶或深部病灶不太适用，这使得消融成为一种有前景的替代方法。
两名具有肾素瘤典型表现（包括高血压、低钾血症、高肾素、高醛固酮和正常ARR）的年轻女性，通过实时超声造影引导下射频消融治疗成功，治疗前后均进行了超声造影以用于诊断和术后评估。之后，她们的血压和实验室检查恢复正常，在分别为期32个月和6个月的随访中保持稳定。
超声造影引导下射频消融是肾素瘤治疗的一种有前景的替代方法，其安全性和有效性与手术相当，尤其在小病灶或深部病灶方面具有优势。
