单金纳米颗粒驱动的血红素辅因子纳米酶作为一种前所未有的氧化酶模拟物。
Single gold nanoparticle-driven heme cofactor nanozyme as an unprecedented oxidase mimetic.
机构信息
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, P. R. China.
出版信息
Chem Commun (Camb). 2021 Apr 7;57(27):3399-3402. doi: 10.1039/d1cc00279a. Epub 2021 Mar 9.
PMID:33686388
Abstract
The catalytic diversity of heme enzymes is a perpetuating pursuit for biomimetic chemistry, but heme nanozymes exhibit catalytic activity only reminiscent of peroxidases. Miraculously, the oxidase-like catalytic function of a heme cofactor is elicited with the help of gold nanoparticles (AuNPs) by maintaining heme with a low-valence state (ferrous) in a confined configuration.
摘要
血红素酶的催化多样性是仿生化学不断追求的目标，但血红素纳米酶仅表现出类似于过氧化物酶的催化活性。神奇的是，通过在受限构象中保持低氧化态（亚铁），血红素辅因子的氧化酶样催化功能在金纳米粒子（AuNPs）的帮助下被激发。
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