中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对转移性结直肠癌的预后意义。
Prognostic Significance of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Metastatic Colorectal Cancer.
机构信息
Defne Hospital, Division of Medical Oncology, Hatay, Turkey.
Division of Hematology, Ankara City Hospital, Ankara, Turkey.
出版信息
J Gastrointest Cancer. 2022 Mar;53(1):1-6. doi: 10.1007/s12029-021-00616-y. Epub 2021 Mar 9.
UNLABELLED
There are many studies on the biomarkers for the prognosis in the treatment of metastatic colorectal cancer. Neutrophil-lymphocyte radio (NLR) and platelet-lymphocyte radio (PLR) are of interest with studies revealing the relationship between inflammatory biomarkers and cancer. Our study is a retrospective file study and the contribution of NLR and PLR to progression-free survival (PFS) and overall survival (OS) before first-line chemotherapy was investigated regardless of treatment. The cutoff values of NLR and PLR were determined using ROC curve analysis. NLR and PLR were divided into two groups according to the cut-off points. OS and PFS associated with NLR and PLR were performed by the Kaplan-Meier method. In our study, we could not demonstrate the prognostic potential of pre-treatment NLR and PLR in patients with mCRC treated with first-line chemotherapy. Our study showed that the use of these biomarkers in mCRC is limited.
INTRODUCTION
There are many studies on the biomarkers for the prognosis in the treatment of metastatic colorectal cancer. Neutrophil-lymphocyte radio (NLR) and platelet-lymphocyte radio (PLR) are of interest with studies revealing the relationship between inflammatory biomarkers and cancer.
MATERIAL AND METHOD
Our study is a retrospective file study and the contribution of NLR and PLR to progression-free survival (PFS) and overall survival (OS) before first-line chemotherapy was investigated regardless of treatment. The cutoff values of NLR and PLR were determined using ROC curve analysis. NLR and PLR were divided into two groups according to the cut-off points. OS and PFS associated with NLR and PLR were performed by the Kaplan-Meier method.
RESULT
In our study, we could not demonstrate the prognostic potential of pre-treatment NLR and PLR in patients with mCRC treated with first-linechemotherapy.
CONCLUSION
Our study showed that the use of these biomarkers in mCRC is limited.
目的
探讨中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在转移性结直肠癌（mCRC）一线化疗前对无进展生存期（PFS）和总生存期（OS）的预测价值。
材料和方法
回顾性分析 mCRC 患者的临床病理资料，采用 ROC 曲线确定 NLR 和 PLR 的最佳截断值，根据截断值将患者分为高 NLR 和高 PLR 组与低 NLR 和低 PLR 组，采用 Kaplan-Meier 法比较两组患者的 OS 和 PFS。
结果
多因素分析显示，NLR 和 PLR 与 mCRC 患者的 OS 和 PFS 无关。
结论
本研究表明，NLR 和 PLR 对 mCRC 患者一线化疗的预后预测价值有限。
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