血小板与淋巴细胞比值可预测转移性结直肠癌的预后：一项综述与荟萃分析
The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis.
作者信息
Wang Jinming, Li Jing, Wei Sheng, Xu Jie, Jiang Xiaohui, Yang Lei
机构信息
Cancer Research Center Nantong, Nantong Tumor Hospital & Affiliated Tumor Hospital of Nantong University, Nantong, China.
Department of General Surgery, Nantong Tumor Hospital & Affiliated Tumor Hospital of Nantong University, Nantong, China.
出版信息
Gastroenterol Res Pract. 2021 Nov 2;2021:9699499. doi: 10.1155/2021/9699499. eCollection 2021.
BACKGROUND
In recent years, the incidence of colorectal cancer (CRC) has continued to increase. Although the overall prognosis of CRC has improved with the continuous improvement of the level of treatment, the prognosis of metastatic colorectal cancer (mCRC) is still poor. The purpose of our study is to explore the prognostic value of platelet to lymphocyte ratio (PLR) in mCRC.
METHODS
The PubMed, Web of Science, and Embase (via OVID) were systematically searched to obtain all relevant research. We used hazard ratio (HR) with 95% confidence interval (CI) to assess the associations of PLR and overall survival (OS) and progression free survival (PFS).
RESULTS
A total of twelve studies containing 1452 patients were included in this meta-analysis. Pooled analysis showed that high levels of PLR were associated with poor OS (HR: 1.72, 95% CI: 1.27-2.33, and < 0.01) and PFS (HR: 1.64, 95% CI: 1.16-2.31, and = 0.033).
CONCLUSION
Our analysis suggested that high levels of PLR pretreatment may be an effective predictive biomarker for the prognosis of mCRC patients.
背景
近年来，结直肠癌（CRC）的发病率持续上升。尽管随着治疗水平的不断提高，CRC的总体预后有所改善，但转移性结直肠癌（mCRC）的预后仍然很差。我们研究的目的是探讨血小板与淋巴细胞比值（PLR）在mCRC中的预后价值。
方法
系统检索PubMed、科学网和Embase（通过OVID）以获取所有相关研究。我们使用风险比（HR）及95%置信区间（CI）来评估PLR与总生存期（OS）和无进展生存期（PFS）之间的关联。
结果
本荟萃分析共纳入12项研究，包含1452例患者。汇总分析显示，高水平的PLR与较差的OS（HR：1.72，95%CI：1.27 - 2.33，P<0.01）和PFS（HR：1.64，95%CI：1.16 - 2.31，P = 0.033）相关。
结论
我们的分析表明，治疗前高水平的PLR可能是mCRC患者预后的有效预测生物标志物。
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