Key Laboratory of Brain, Cognition and Education Sciences (Ministry of Education), Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health & Cognitive Science, School of Psychology, South China Normal University, Guangzhou, China.
School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
J Sleep Res. 2021 Oct;30(5):e13329. doi: 10.1111/jsr.13329. Epub 2021 Mar 8.
A series of studies have shown that sleep loss impairs one's capability for sustained attention. However, the underlying neurobiological mechanism linking sleep loss with sustained attention has not been elucidated. The present study aimed to investigate the effect of sleep deprivation on the resting-state brain and explored whether the magnitude of vigilance impairment after acute sleep deprivation can be predicted by measures of spontaneous fluctuations and functional connectivity. We implemented resting-state functional magnetic resonance imaging with 42 participants under both normal sleep and 24-hr sleep-deprivation conditions. The amplitude of low-frequency fluctuations (ALFF) and functional connectivity was used to investigate the neurobiological change caused by sleep deprivation, and the psychomotor vigilance task (PVT) was used to measure sustained attention in each state. Correlation analysis was used to investigate the relationship between the change in ALFF/functional connectivity and vigilance performance. Sleep deprivation induced significant reductions in ALFF in default mode network nodes and frontal-parietal network nodes, while inducing significant increments of ALFF in the bilateral thalamus, motor cortex, and visual cortex. The increased ALFF in the visual cortex was correlated with increased PVT lapses. Critically, decreased frontal-thalamus connectivity was correlated with increased PVT lapses, while increased frontal-visual connectivity was correlated with increased PVT lapses. The findings indicated that acute sleep deprivation induced a robust alteration in the resting brain, and sustained attentional impairment after sleep deprivation could be predicted by altered frontal connectivity with crucial neural nodes of stimulus input, such as the thalamus and visual cortex.
一系列研究表明，睡眠不足会损害人们持续注意力的能力。然而，将睡眠不足与持续注意力联系起来的潜在神经生物学机制尚未阐明。本研究旨在探讨睡眠剥夺对静息态大脑的影响，并探索急性睡眠剥夺后警觉性损害的程度是否可以通过自发性波动和功能连接的测量来预测。我们在正常睡眠和 24 小时睡眠剥夺两种条件下，对 42 名参与者进行了静息态功能磁共振成像。采用低频振幅（ALFF）和功能连接来研究睡眠剥夺引起的神经生物学变化，并在每种状态下使用精神运动警觉任务（PVT）测量持续注意力。采用相关分析来研究 ALFF/功能连接变化与警觉性表现之间的关系。睡眠剥夺导致默认模式网络节点和额顶叶网络节点的 ALFF 显著降低，而双侧丘脑、运动皮质和视觉皮质的 ALFF 显著增加。视觉皮质中增加的 ALFF 与 PVT 失误的增加有关。重要的是，额-丘脑连接的降低与 PVT 失误的增加有关，而额-视觉连接的增加与 PVT 失误的增加有关。这些发现表明，急性睡眠剥夺会引起静息态大脑的强烈改变，而睡眠剥夺后持续注意力的损害可以通过与丘脑和视觉皮层等关键刺激输入神经节点的额连接改变来预测。
