Essa Mohamed S, Ahmad Khaled S, Zayed Mohamed E, Ibrahim Samia G
Benha University Hospital, Benha University, Benha, Egypt.
Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia.
Int J Low Extrem Wounds. 2023 Mar;22(1):48-55. doi: 10.1177/1534734620988217. Epub 2021 Mar 9.
We are trying to evaluate silver nanoparticles' effectiveness (SilvrSTAT Gel) in accelerating healing rate of nonischemic diabetic foot ulcers (DFUs).
This prospective, double-blind, randomized, controlled study includes 80 patients with nonischemic DFUs classified into 2 groups. Group A was subjected to SilvrSTAT Gel dressing, and group B was subjected to conventional dressing (wet-to-moist dressing with or without povidone-iodine). All cases had minimal debridement before treatment. In both groups, all cases were nonischemic after successful revascularization either by bypass surgery or endovascular therapy.
The healing rate of the SilvrSTAT group was significantly higher than that of the conventional group. The healing rate per week of the SilvrSTAT group was considerably higher than that of the conventional group ( < .0001). The rate of complete healing for ulcers in group A was achieved in 22 patients (55%) by the 6th week, while 29 (72.5%), 34 (85%), and 36 (90%) patients were healed entirely by the 8th, 10th, and 12th weeks, respectively. In group B: 20 (50%), 27 (67.5%), and 30 (75%) patients were completeley healed by the 8th, 10th, and 12th weeks, respectively.
SilvrSTATGel is effective in the treatment of DFU.
我们正在评估银纳米颗粒（SilvrSTAT凝胶）在加速非缺血性糖尿病足溃疡（DFU）愈合速度方面的有效性。
这项前瞻性、双盲、随机对照研究纳入了80例非缺血性DFU患者，分为两组。A组采用SilvrSTAT凝胶敷料，B组采用传统敷料（湿性至湿性敷料，含或不含聚维酮碘）。所有病例在治疗前均进行了最小限度的清创。两组中，所有病例在通过旁路手术或血管内治疗成功实现血运重建后均为非缺血性。
SilvrSTAT组的愈合率显著高于传统组。SilvrSTAT组每周的愈合率明显高于传统组（<0.0001）。A组溃疡在第6周时22例（55%）实现完全愈合，而在第8、10和12周时分别有29例（72.5%）、34例（85%）和36例（90%）患者完全愈合。B组中，分别在第8、10和12周时20例（50%）、27例（67.5%）和30例（75%）患者完全愈合。
SilvrSTAT凝胶在治疗DFU方面有效。
