Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Centre for Neurological Diseases (NCRC-ND), Beijing, China.
Aging (Albany NY). 2021 Mar 3;13(6):8396-8407. doi: 10.18632/aging.202650.
High on-treatment platelet reactivity (HOPR) is associated with stroke recurrence. It is important to find a reliable method to assess HOPR. We aimed to compare the correlations between VerifyNow™ system, thromboelastography (TEG), and Aggrestar platelet function analyzer (PL-12) on platelet activity in patients with minor ischemic stroke or transient ischemic attack (TIA) after dual antiplatelet therapy for 7 days. About 276 patients were included. Spearman's correlation coefficient and the kappa coefficient were adopted to evaluate associations among the three test methods. An obvious correlation between VerifyNow and TEG on HOPR-ADP (r=0.64, p<0.001) was found. The correlations of HOPR-ADP between PL-12 and the other two platelet function analyzers were moderate (PL-12 versus VerifyNow, r=0.47, p<0.001; PL-12 versus TEG, r=0.25, p<0.001). The correlations of HOPR-AA were limited among these three platelet function analyzers (VerifyNow versus TEG, r=0.09, p=0.14; VerifyNow versus PL-12, r=0.15, p=0.01; PL-12 versus TEG, r=0.10, p=0.09). Correlations among different platelet function analyzers were varied. VerifyNow and TEG were more correlative than PL-12 on HOPR-ADP. The consistence of HOPR-AA was limited among VerifyNow, TEG and PL-12. The proportion of stroke recurrence and composite events in patients with HOPR-ADP assessing by PL-12 was higher than VerifyNow and TEG.
高血小板反应性（HOPR）与中风复发有关。寻找一种可靠的方法来评估 HOPR 非常重要。我们旨在比较VerifyNow™系统、血栓弹力图（TEG）和 Aggrestar 血小板功能分析仪（PL-12）在接受双联抗血小板治疗 7 天后发生小缺血性中风或短暂性脑缺血发作（TIA）的患者中对血小板活性的相关性。共纳入约 276 例患者。采用 Spearman 相关系数和 Kappa 系数评估三种检测方法之间的相关性。VerifyNow 和 TEG 在 HOPR-ADP 方面存在明显相关性（r=0.64，p<0.001）。PL-12 与另外两种血小板功能分析仪之间的 HOPR-ADP 相关性中等（PL-12 与 VerifyNow，r=0.47，p<0.001；PL-12 与 TEG，r=0.25，p<0.001）。三种血小板功能分析仪之间 HOPR-AA 的相关性有限（VerifyNow 与 TEG，r=0.09，p=0.14；VerifyNow 与 PL-12，r=0.15，p=0.01；PL-12 与 TEG，r=0.10，p=0.09）。不同血小板功能分析仪之间的相关性存在差异。VerifyNow 和 TEG 在 HOPR-ADP 方面比 PL-12 更具相关性。VerifyNow、TEG 和 PL-12 之间 HOPR-AA 的一致性有限。PL-12 评估的 HOPR-ADP 患者中，中风复发和复合事件的比例高于 VerifyNow 和 TEG。
