Department of Public Health, Aarhus University, Aarhus, Denmark.
Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Eur J Nutr. 2021 Oct;60(7):3639-3646. doi: 10.1007/s00394-021-02526-y. Epub 2021 Mar 9.
We investigated risk of myocardial infarction (MI) associated with the content of linoleic acid (LA) in adipose tissue, a biomarker of long-term dietary intake of LA and a marker of endogenous LA exposure.
Between 1993 and 1997, 57,053 middle-aged subjects were included in the Danish Diet, Cancer and Health cohort. We performed a case-cohort study that included a random sample of the full cohort (n = 3167) and all incident MI cases appearing during 16 years of follow-up (n = 2819). Information on incident MI cases was obtained by linkage with Danish nationwide registries. Adipose tissue biopsies were taken from the buttocks of the participants, and their fatty acid composition was determined using gas chromatography. HRs (hazard ratios) with 95% confidence intervals (CIs) were used to describe the associations between content of LA in adipose tissue and the risk of MI. HRs were calculated using weighted Cox proportional hazards regression with robust variance.
After adjustment for established risk factors of MI, adipose tissue content of LA was not associated with the risk of MI in men and women combined (quintiles 5 versus 1, HR, 1.03 (95% CI, 0.85-1.25), P-trend = 0.970) or in men and women separately (quintiles 5 versus 1, HR, 1.05 (95% CI, 0.83-1.33), P-trend = 0.871 and quintiles 5 versus 1, HR, 0.99 (95% CI 0.72-1.37), P-trend = 0.928, respectively). Investigating the association between LA and MI with a shorter, 5- or 10-year duration of follow-up provided similar results.
Content of LA in adipose tissue was not associated with the risk of MI.
我们研究了脂肪组织中亚油酸（LA）含量与心肌梗死（MI）风险的关系，脂肪组织中 LA 含量是长期 LA 饮食摄入的生物标志物，也是内源性 LA 暴露的标志物。
1993 年至 1997 年期间，共有 57053 名中年参与者纳入丹麦饮食、癌症与健康队列研究。我们进行了病例-队列研究，其中包括队列的随机样本（n=3167）和 16 年随访期间出现的所有 MI 病例（n=2819）。通过与丹麦全国性登记处的链接获取 MI 病例的信息。从参与者的臀部采集脂肪组织活检，并使用气相色谱法测定其脂肪酸组成。使用加权 Cox 比例风险回归和稳健方差计算风险比（HR）和 95%置信区间（CI）来描述脂肪组织中 LA 含量与 MI 风险之间的关系。
在校正 MI 的既定危险因素后，LA 在脂肪组织中的含量与男女混合人群（五分位数 5 与 1 相比，HR 为 1.03（95%CI，0.85-1.25），P 趋势=0.970）或男女分别人群（五分位数 5 与 1 相比，HR 为 1.05（95%CI，0.83-1.33），P 趋势=0.871 和五分位数 5 与 1 相比，HR 为 0.99（95%CI 0.72-1.37），P 趋势=0.928）的 MI 风险无关。用较短的 5 年或 10 年随访时间来研究 LA 与 MI 之间的关系，结果相似。
脂肪组织中 LA 含量与 MI 风险无关。
