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Re-sleeping after reversal of remimazolam by flumazenil.

作者信息

Yamamoto Tomohiro, Kurabe Miyuki, Kamiya Yoshinori

机构信息

Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo ward, Niigata, 951-8510, Japan.

出版信息

J Anesth. 2021 Apr;35(2):322. doi: 10.1007/s00540-021-02915-x. Epub 2021 Mar 9.

DOI:10.1007/s00540-021-02915-x
PMID:33687549
Abstract
摘要

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Re-sleeping after reversal of remimazolam by flumazenil.氟马西尼逆转瑞米唑仑作用后再次入睡。
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Caution!! Reappearance of remimazolam effect after a flumazenil bolus: a larger bolus of flumazenil and a lower total remimazolam clearance are higher risks.注意！！氟马西尼推注后瑞米唑仑效应再现：更大剂量的氟马西尼推注和更低的瑞米唑仑总清除率风险更高。
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Remimazolam should be antagonized by an adequate flumazenil.瑞马唑仑应用适当剂量的氟马西尼拮抗。
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Predicting the amount of flumazenil needed to antagonize remimazolam.预测拮抗瑞马唑仑所需氟马西尼的用量。
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Simulation of residual sedation effect of remimazolam: pharmacokinetic-pharmacodynamic simulation can be an additional standard anesthesia monitoring method.瑞马唑仑残余镇静效应的模拟：药代动力学-药效学模拟可成为一种额外的标准麻醉监测方法。
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A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. Safety, efficacy, and basic pharmacokinetics.一项安慰剂和咪达唑仑对照的 I 期单递增剂量研究，评估 remimazolam（CNS 7056）的安全性、药代动力学和药效学：第 I 部分。安全性、疗效和基本药代动力学。
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Reversal of midazolam-induced laryngospasm with flumazenil.氟马西尼逆转咪达唑仑引起的喉痉挛
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Differentiating the sedative, psychomotor and amnesic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist, flumazenil.区分苯二氮䓬类药物的镇静、精神运动和遗忘作用：一项关于咪达唑仑和苯二氮䓬类拮抗剂氟马西尼的研究。
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