Health Economics and Decision Science, The University of Sheffield School of Health and Related Research, Sheffield, UK.
Cornea and Anterior Segment Services, Dr Shroff's Charity Eye Hospital Delhi, New Delhi, Delhi, India.
Br J Ophthalmol. 2022 Jul;106(7):923-928. doi: 10.1136/bjophthalmol-2020-318642. Epub 2021 Mar 9.
To report the global uptake of simple limbal epithelial transplantation (SLET) and compare the economic, clinical and social outcomes of SLET with those of cultured limbal epithelial transplantation (CLET).
A comprehensive literature review and an online survey of eye surgeons were conducted to understand the efficacy and current uptake of SLET surgery. A de novo economic model was developed to estimate the cost savings with SLET compared with CLET. Our economic analysis is conducted from an Indian perspective, as this is where the technique originated. A scenario analysis using the UK cost data and a user-friendly Excel model is included to allow users to input the costs from their setting to estimate the cost savings with using SLET compared with using CLET RESULTS: The anatomical success with SLET in adults (72.6% (range 62%-80%)) was the same as CLET (70.4% (range 68%-80.9%)). For children, the outcome for SLET (77.8% (range 73%-83%)) was better than with CLET (44.5% (range 43%-45%)). In response to our informal questionnaire, 99 surgeons reported to have performed SLET on 1174 patients in total. They appreciated that SLET negates the requirement for costly tissue engineering facilities. Results of economic analysis suggested that SLET provided an estimated cost-savings of US$6470.88 for adults and US$6673.10 for children. In broad terms, the cost of SLET is approximately 10% of the cost of CLET for adults and 8% for children.
SLET offers a more accessible and financially attractive alternative to CLET to treat limbal stem cell deficiency.
报告简单的角膜缘上皮移植术（SLET）在全球的应用情况，并比较 SLET 与培养的角膜缘上皮移植术（CLET）的经济、临床和社会结果。
通过全面的文献回顾和对眼科医生的在线调查，了解 SLET 手术的疗效和当前应用情况。建立了一个新的经济模型，以估计与 CLET 相比，SLET 的成本节约。我们的经济分析是从印度的角度进行的，因为这项技术起源于印度。包括使用英国成本数据的情景分析和用户友好的 Excel 模型，允许用户输入其所在地区的成本，以估计与使用 CLET 相比，使用 SLET 的成本节约。
成人 SLET 的解剖成功率为 72.6%（范围为 62%-80%），与 CLET 相同（70.4%（范围为 68%-80.9%））。对于儿童，SLET 的结果（77.8%（范围为 73%-83%））优于 CLET（44.5%（范围为 43%-45%））。在我们的非正式问卷调查中，99 名外科医生报告总共对 1174 名患者进行了 SLET 手术。他们认为 SLET 无需昂贵的组织工程设施。经济分析结果表明，SLET 为成人提供了约 6470.88 美元的成本节约，为儿童提供了约 6673.10 美元的成本节约。从广义上讲，SLET 的成本约为成人 CLET 成本的 10%，儿童 CLET 成本的 8%。
SLET 为治疗角膜缘干细胞缺陷提供了一种更易于获得且更具吸引力的经济替代方案，优于 CLET。
