Nehra Ashima, Sharma Priya S, Narain Avneesh, Kumar Amit, Bajpai Swati, Rajan Roopa, Kumar Nand, Goyal Vinay, Srivastava Achal K
Division of Neuropsychology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Ann Indian Acad Neurol. 2020 Nov-Dec;23(6):755-759. doi: 10.4103/aian.AIAN_70_20. Epub 2020 May 21.
Parkinson's disease (PD) is a neurodegenerative disorder which greatly affects patients' quality of life. Despite an exponential increase in PD cases, not much attention has been paid to enhancing their quality of life (QoL). Thus, this systematic review aims to summarize the available literature for the role of repetitive transcranial magnetic stimulation (rTMS) intervention to improve QoL of PD patients.
Literature review was carried out using PubMed, Embase, Web of Science and Scopus databases. The key search words were, "", "". Cochrane Collaboration software 5.3 was used to assess the quality of studies.
Over 707 studies were identified out of which 5 studies were included which consisted of 160 subjects, 89 male and 71 female, with mean age of 65.04 years. PD type varied from idiopathic PD, rigid, akinetic, tremor dominant to mixed type. The overall risk of bias across the studies was low and unclear with high risk of bias in domain in one study.
The efficacy of rTMS as an adjunct intervention to enhance QoL of PD patients is uncertain due to dire lack of research in this area. The findings of the present review would help researchers conduct a well-defined, randomized, controlled trial by overcoming the present limitations associated with rTMS intervention to improve QoL of PD patients.
帕金森病（PD）是一种神经退行性疾病，严重影响患者的生活质量。尽管帕金森病病例呈指数级增长，但在提高患者生活质量（QoL）方面却未得到足够重视。因此，本系统评价旨在总结现有文献中重复经颅磁刺激（rTMS）干预对改善帕金森病患者生活质量的作用。
使用PubMed、Embase、科学网和Scopus数据库进行文献综述。关键检索词为“”、“”。使用Cochrane协作软件5.3评估研究质量。
共识别出707项以上研究，其中纳入5项研究，共160名受试者，男性89名，女性71名，平均年龄65.04岁。帕金森病类型包括特发性帕金森病、强直型、运动不能型、震颤为主型和混合型。各项研究的总体偏倚风险较低且不明确，一项研究在某领域存在高偏倚风险。
由于该领域研究严重不足，rTMS作为辅助干预措施提高帕金森病患者生活质量的疗效尚不确定。本综述的结果将有助于研究人员克服与rTMS干预相关的现有局限性，开展明确的随机对照试验，以改善帕金森病患者的生活质量。
