Fatima Javeria, Siddique Yasir Hasan
Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
CNS Neurol Disord Drug Targets. 2025;24(2):144-157. doi: 10.2174/0118715273325789240904065214.
The prevalence of neurodegenerative diseases has increased with longer life expectancies, necessitating the exploration of novel neuroprotective agents. Tangeretin, a polymethoxylated flavone derived from citrus fruits, has gathered attention for its potential therapeutic effects. This review highlights the neuroprotective properties of tangeretin via its antioxidant and anti-inflammatory mechanisms. Tangeretin demonstrates efficacy in mitigating oxidative stress, neuroinflammation, and neuronal damage across various neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, and epilepsy. It shows promise in ameliorating cognitive deficits and memory impairments associated with these diseases. Moreover, tangeretin modulates multiple signalling pathways and protects against neuronal apoptosis, underscoring its potential as a therapeutic agent.
随着预期寿命的延长，神经退行性疾病的患病率有所上升，因此有必要探索新型神经保护剂。橘皮素是一种源自柑橘类水果的多甲氧基黄酮，因其潜在的治疗作用而受到关注。本综述强调了橘皮素通过其抗氧化和抗炎机制所具有的神经保护特性。橘皮素在减轻各种神经退行性疾病（包括阿尔茨海默病、帕金森病、脑缺血和癫痫）中的氧化应激、神经炎症和神经元损伤方面显示出疗效。它在改善与这些疾病相关的认知缺陷和记忆障碍方面展现出前景。此外，橘皮素可调节多种信号通路并防止神经元凋亡，凸显了其作为治疗剂的潜力。
