Yang Hua, Gao Jian, Li Shuyu, Xia Huiling, Chen Zhangyan, Zhu Shanzhu, Pan Zhigang
Department of General Practice, Zhongshan Hospital of Fudan University, Shanghai, 200030, People's Republic of China.
Department of Nutrition, Zhongshan Hospital of Fudan University, Center of Clinical Epidemiology and Evidence-Based Medicine, Fudan University, Shanghai, 200030, People's Republic of China.
Int J Gen Med. 2021 Mar 1;14:687-695. doi: 10.2147/IJGM.S300196. eCollection 2021.
Serum uric acid (sUA) level has been reported to be associated with arteriosclerotic cardiovascular risk, yet remains poorly defined in Chinese type 2 diabetes patients. The purpose of the current study was to evaluate gender differences in the association between sUA level and arteriosclerotic cardiovascular risk in Chinese type 2 diabetes patients.
The cross-sectional study was conducted in six community health service centers in Shanghai, China from December 2014 to December 2016. A stratified random sampling method was used to recruit participants. From a total of 3977 type 2 diabetic patients, 2537 were included for the analysis of the association between sUA level and arteriosclerotic cardiovascular risk. Clinical and biochemical data were obtained from participants. Arteriosclerotic cardiovascular risk was evaluated by the ten-year risk profile for arteriosclerotic cardiovascular disease. The associations between sUA level and arteriosclerotic cardiovascular risk were assessed via multiple logistic regression.
Of the 2537 participants, the average sUA level was 317±77umol/L in men and 294±73 umol/L in women, and 54.8% (1391/2537) of participants had high ten-year risk of arteriosclerotic cardiovascular disease (ASCVD), which was ≥20%. High ten-year risk of ASCVD odds ratio was increased by 1.596 (95% CI, 1.113-2.289, for trend 0.004) comparing fourth to first quartiles of sUA in women. However, no significant association was found between sUA and high ten-year risk of ASCVD in men.
This community-based study indicated that sUA levels were independently associated with high ten-year risk of ASCVD in women with type 2 diabetes mellitus, but not in men.
血清尿酸（sUA）水平已被报道与动脉粥样硬化性心血管疾病风险相关，但在中国2型糖尿病患者中仍未得到明确证实。本研究的目的是评估中国2型糖尿病患者中sUA水平与动脉粥样硬化性心血管疾病风险之间的性别差异。
本横断面研究于2014年12月至2016年12月在中国上海的6个社区卫生服务中心进行。采用分层随机抽样方法招募参与者。从总共3977例2型糖尿病患者中，纳入2537例分析sUA水平与动脉粥样硬化性心血管疾病风险之间的关系。从参与者处获取临床和生化数据。通过动脉粥样硬化性心血管疾病的十年风险评估来评估动脉粥样硬化性心血管疾病风险。通过多因素逻辑回归评估sUA水平与动脉粥样硬化性心血管疾病风险之间的关系。
在2537名参与者中，男性的平均sUA水平为317±77μmol/L，女性为294±73μmol/L，54.8%（1391/2537）的参与者有十年动脉粥样硬化性心血管疾病（ASCVD）高风险，即≥20%。与sUA水平的第一四分位数相比，女性中ASCVD十年高风险的优势比增加了1.596（95%CI，1.113 - 2.289，趋势P = 0.004）。然而，在男性中未发现sUA与ASCVD十年高风险之间存在显著关联。
这项基于社区的研究表明，sUA水平与2型糖尿病女性的ASCVD十年高风险独立相关，但与男性无关。
