Oltean Irina, Tran Jason, Lawrence Sarah, Ruschkowski Brittany Ann, Zeng Na, Bardwell Cameron, Nasr Youssef, de Nanassy Joseph, El Demellawy Dina
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, K1H 8L1, Canada.
Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada.
Heliyon. 2021 Mar;7(3):e06393. doi: 10.1016/j.heliyon.2021.e06393. Epub 2021 Mar 2.
Pregnant women are susceptible to viral infections due to physiological changes such as cell-mediated immunity. No severe adverse pregnancy or neonatal outcomes have been consistently reported in 2019 novel coronavirus disease (COVID-19) positive pregnancy cases. There are controversies around the role of COVID-19 in pregnancy. A systematic review was conducted to examine clinical maternal and neonatal clinical outcomes. Studies were included if they reported SARS-CoV-2 infection among pregnant women and/or COVID-19 positive neonates as validated by positive antibody testing or viral testing using polymerase chain reaction. Case series, case reports, case-control studies, and comparative studies were included. Eight hundred and thirty-seven records were identified, resulting in 525 records for level I screening. Forty-one were included after full-text review. Results suggest elevated rates of intensive care unit (ICU) admission, gestational diabetes, preeclampsia, C-sections, pre-term birth, and C-reactive protein (CRP) in comparison to pregnant women without SARS-CoV-2. Careful monitoring of pregnancies with SARS-CoV-2 is recommended.
由于细胞介导免疫等生理变化，孕妇易受病毒感染。在新型冠状病毒肺炎（COVID-19）阳性孕妇病例中，尚未有一致报告的严重不良妊娠或新生儿结局。关于COVID-19在妊娠中的作用存在争议。进行了一项系统综述以检查孕产妇和新生儿的临床结局。如果研究报告了孕妇中SARS-CoV-2感染和/或经抗体检测阳性或使用聚合酶链反应进行病毒检测验证的COVID-19阳性新生儿，则纳入研究。纳入了病例系列、病例报告、病例对照研究和比较研究。共识别出837条记录，一级筛查后得到525条记录。全文审查后纳入41条。结果表明，与未感染SARS-CoV-2的孕妇相比，重症监护病房（ICU）入院率、妊娠期糖尿病、先兆子痫、剖宫产、早产和C反应蛋白（CRP）升高。建议对感染SARS-CoV-2的孕妇进行仔细监测。
