Iagoda A V, Smirnova O V, Mosin V I
Ter Arkh. 1988;60(2):54-8.
A study was made of the indices of lipid peroxidation (LPO)--conjugated dienes (CD) and diene ketones (D), cyclic nucleotides (CN)--cAMP and cGMP, prostaglandins (PG) E and F2 alpha in biopsy tissue of the liver in 55 patients with chronic hepatitis (CH) and liver cirrhosis (LC). LPO was determined by spectrophotometry, CH and LC--by a radioimmunoassay. In patients with CPH and CAH the indices of LPO and cGMP were normal, cAMP, PG and PGE/PGF2 alpha were raised. In a severe fast progressive liver lesion disorder of coordination activity of the cell membranous systems was characterized by a high LPO activity, a decrease in cAMP and relative deficit of liver PG.
对55例慢性肝炎（CH）和肝硬化（LC）患者肝脏活检组织中的脂质过氧化指标（LPO）——共轭二烯（CD）和二烯酮（D）、环核苷酸（CN）——环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）、前列腺素（PG）E和F2α进行了研究。LPO通过分光光度法测定，CH和LC通过放射免疫测定法测定。在慢性持续性肝炎（CPH）和慢性活动性肝炎（CAH）患者中，LPO和cGMP指标正常，cAMP、PG以及PGE/PGF2α升高。在严重的快速进展性肝脏病变中，细胞膜系统协调活性紊乱的特征是LPO活性高、cAMP降低以及肝脏PG相对缺乏。
