叶酸生物合成抑制剂。1. 蝶啶衍生物对二氢新蝶呤醛缩酶的抑制作用。
Inhibitors of folate biosynthesis. 1. Inhibition of dihydroneopterin aldolase by pteridine derivatives.
作者信息
Zimmerman M, Tolman R L, Morman H, Graham D W, Rogers E F
出版信息
J Med Chem. 1977 Sep;20(9):1213-5. doi: 10.1021/jm00219a021.
PMID:336889
Abstract
2-Amino-6-carboxamido-7,8-dihydropteridin-4-one and 2-amino-6-hydroxymethyl-7,7-dimethyl-7,8-dihydropteridin-4-one have been shown to be good inhibitors of Escherichia coli dihydroneopterin aldolase, an early enzyme of de novo folate biosynthesis.
摘要
2-氨基-6-甲酰胺基-7,8-二氢蝶啶-4-酮和2-氨基-6-羟甲基-7,7-二甲基-7,8-二氢蝶啶-4-酮已被证明是大肠杆菌二氢新蝶呤醛缩酶的良好抑制剂，该酶是叶酸从头生物合成的早期酶。
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