Zimmerman M, Tolman R L, Morman H, Graham D W, Rogers E F
J Med Chem. 1977 Sep;20(9):1213-5. doi: 10.1021/jm00219a021.
2-Amino-6-carboxamido-7,8-dihydropteridin-4-one and 2-amino-6-hydroxymethyl-7,7-dimethyl-7,8-dihydropteridin-4-one have been shown to be good inhibitors of Escherichia coli dihydroneopterin aldolase, an early enzyme of de novo folate biosynthesis.
2-氨基-6-甲酰胺基-7,8-二氢蝶啶-4-酮和2-氨基-6-羟甲基-7,7-二甲基-7,8-二氢蝶啶-4-酮已被证明是大肠杆菌二氢新蝶呤醛缩酶的良好抑制剂，该酶是叶酸从头生物合成的早期酶。
