脊椎动物造血干细胞命运决定的转录和表观遗传控制。
Transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates.
机构信息
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101, Beijing, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101, Beijing, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Dev Biol. 2021 Jul;475:156-164. doi: 10.1016/j.ydbio.2021.03.003. Epub 2021 Mar 6.
Hematopoietic stem cells (HSCs) are the foundation of adult hematopoiesis that produce all types of mature blood lineages. In vertebrates, HSC development is a stepwise process, coordinately regulated by chromatin architectures and a group of transcriptional and epigenetic regulators. A deeper understanding of the molecular mechanisms governing the generation, expansion, and function of HSCs holds great promise in the generation and expansion of engraftable HSCs in vitro for clinical applications. This study reviewed recent advances in transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates.
造血干细胞（HSCs）是成人造血的基础，能够产生所有类型的成熟血液谱系。在脊椎动物中，HSC 的发育是一个逐步的过程，由染色质结构和一组转录和表观遗传调节剂协调调节。深入了解调控 HSCs 生成、扩增和功能的分子机制，有望在体外生成和扩增可移植的 HSCs 用于临床应用方面取得进展。本研究综述了近年来在脊椎动物造血干细胞命运决定的转录和表观遗传调控方面的进展。
Zotero 插件