Yunnan Key Laboratory of Southern Medicinal Resource, Yunnan University of Chinese Medicine, Kunming 650500, People's Republic of China.
Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Fitoterapia. 2021 Jun;151:104879. doi: 10.1016/j.fitote.2021.104879. Epub 2021 Mar 6.
Swertia mileensis, known as Qing-Ye-Dan (QYD), has been documented in Chinese Pharmacopoeia to cure hepatitis. Interestingly, its announced main active component, swertiamarin, could not be detected in the decoction, which indicated that the efficacy of QYD might be attributed to heat-transformed products of swertiamarin (HTPS). Further investigation on HTPS led to the isolation of sweritranslactone D (1), a novel secoiridoid dimer possessing a tetracyclic lactone skeleton, with better hepatoprotective activity than N-acetyl-L-cysteine in vitro.
川西獐牙菜，又称青叶胆，在中国药典中被记载用于治疗肝炎。有趣的是，其宣称的主要活性成分獐牙菜苦苷并未在煎剂中检测到，这表明青叶胆的疗效可能归因于獐牙菜苦苷的热转化产物（HTPS）。对 HTPS 的进一步研究导致了 sweritranslactone D（1）的分离，这是一种新型的环烯醚萜二聚体，具有四环内酯骨架，体外肝保护活性优于 N-乙酰-L-半胱氨酸。
