Graduate school of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi,Uncorrected proof. Tokushima 770-8505, Japan.
Department of Clinical Pharmacy, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima 770-8503, Japan.
Fitoterapia. 2013 Dec;91:166-172. doi: 10.1016/j.fitote.2013.08.006. Epub 2013 Aug 27.
Rigenolide A (1), a new secoiridoid glucoside with a cyclobutane skeleton and three new acylated secoiridoid glucosides, 2'-(2,3-dihydroxybenzoyl)-gentiopicroside (2), 2'-(2,3-dihydroxybenzoyl)-swertiamarin (3), 3'-(2,3-dihydroxybenzoyl)-sweroside (4), along with two noriridoids (7 and 8) and two known secoiridoid glucosides (5 and 6), were isolated from Gentiana rigescens Franch. The structures of new compounds were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for DPPH free-radical scavenging activity.
瑞香内酯 A（1），一种新型的环丁烷骨架倍半萜苷和三个新的酰化的裂环环烯醚萜苷，2'-(2,3-二羟基苯甲酰基)-龙胆苦苷（2），2'-(2,3-二羟基苯甲酰基)-当药苦苷（3），3'-(2,3-二羟基苯甲酰基)-swertioside（4），以及两个诺瑞香烷二萜（7 和 8）和两个已知的裂环环烯醚萜苷（5 和 6），从秦艽中分离得到。通过广泛的光谱分析阐明了新化合物的结构。对分离得到的化合物进行了 DPPH 自由基清除活性评价。
