Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Alkafeel, Al-Najaf, Iraq.
Department of Pharmacology, College of Pharmacy, University of Alkafeel, Al-Najaf, Iraq.
J Infect Dev Ctries. 2021 Mar 7;15(2):209-213. doi: 10.3855/jidc.13960.
Coronavirus disease 2019 (COVID-19) is declared as pandemic by the World Health Orgnazation (WHO) on March 2020. One of the heavily utilized measures during this pandemic is vitamin C (aka ascorbic acid). Unfortunately, vitamin C has been associated with glucose measurement interference and thus this study highlights the elevated levels of blood glucose correlated with the presence of vitamin C interference.
Thirty samples were selected randomly and the blood glucose were measured prior and post the addition of spiked standard concentrations of vitamin C. The interference of vitamin C with glucose readings in COVID-19 pandemic were evaluated and observed employing the Auto Chemistry Analyzer machine.
The addition of ascorbic acid (vitamin C) standards (spikes) into the isolated samples shows a correlated increment in the reading measures. Thereafter, the increments of Random Blood Sugar (RBS) readings after being spiked with the vitamin C standards shows a logarithmic correlation with good interesting R-squared (R2 = 0.9921).
The authors find that the presence of vitamin C in blood actively and significantly alters the glucose level readings especially with the highly consumption of vitamin C during the COVID-19 pandemic.
世界卫生组织(WHO)于 2020 年 3 月宣布 2019 年冠状病毒病(COVID-19)为大流行。在大流行期间,大量使用的措施之一是维生素 C(又名抗坏血酸)。不幸的是,维生素 C 与葡萄糖测量干扰有关,因此本研究强调了与维生素 C 干扰存在相关的血糖升高。
随机选择 30 个样本,并在添加维生素 C 标准浓度后测量血糖。使用自动化学分析仪评估维生素 C 对 COVID-19 大流行中葡萄糖读数的干扰并进行观察。
在分离样本中添加抗坏血酸(维生素 C)标准品(加标)会导致读数测量值呈相关性增加。此后,用维生素 C 标准品加标后随机血糖(RBS)读数的增量与良好的有趣 R 平方(R2 = 0.9921)呈对数相关。
作者发现,血液中维生素 C 的存在会积极且显著改变血糖读数,特别是在 COVID-19 大流行期间大量摄入维生素 C 时。