Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia.
Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia.
J Infect Dev Ctries. 2021 Mar 7;15(2):224-229. doi: 10.3855/jidc.13922.
Coronavirus disease 2019 (COVID-19) has been associated with cardiac arrhythmias. Several electrocardiographic markers have been used to predict the risk of arrhythmia in patients with COVID-19. We aim to investigate the electrocardiographic (ECG) ventricular repolarization indices in patients with COVID-19.
We performed a comprehensive systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and Google Scholar Preprint Servers. The primary endpoints of this search were: Tp-e (T-peak-to-T-end) interval, QTd (QT dispersion), and Tp-e/QTc ratio in patients with newly diagnosed COVID-19 from inception up until August 2020.
There were a total of 241 patients from 2 studies. Meta-analysis showed that Tp-e/QTc ratio was higher in COVID-19 group (mean difference 0.02 [0.01, 0.02], p < 0.001; I2: 18%,). Tp-e interval was more prolonged in COVID-19 group (mean difference 7.76 [3.11, 12.41], p < 0.001; I2: 80%) compared to control group. QT dispersion (QTd) also was increased in COVID-19 group (mean difference 1.22 [0.61, 1.83], p < 0.001 ; I2:30%).
Several electrocardiographic markers including Tp-e/QTc, Tp-e interval, and QTd are significantly increased in patients with COVID-19.
新型冠状病毒病 2019（COVID-19）与心律失常有关。已经使用了几种心电图标记物来预测 COVID-19 患者发生心律失常的风险。我们旨在研究 COVID-19 患者的心电图（ECG）心室复极指数。
我们从 PubMed、EuropePMC、SCOPUS、Cochrane 中央数据库和 Google Scholar 预印本服务器进行了全面的系统文献检索。该搜索的主要终点是：从发病到 2020 年 8 月期间新诊断为 COVID-19 的患者的 Tp-e（T 波峰至 T 波末）间期、QTd（QT 离散度）和 Tp-e/QTc 比值。
共有来自 2 项研究的 241 名患者。荟萃分析显示，COVID-19 组的 Tp-e/QTc 比值较高（平均差异 0.02 [0.01，0.02]，p < 0.001；I2：18%）。与对照组相比，COVID-19 组的 Tp-e 间期延长（平均差异 7.76 [3.11，12.41]，p < 0.001；I2：80%）。COVID-19 组的 QT 离散度（QTd）也增加（平均差异 1.22 [0.61，1.83]，p < 0.001；I2：30%）。
几种心电图标记物，包括 Tp-e/QTc、Tp-e 间期和 QTd，在 COVID-19 患者中明显增加。
