Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Periodontol 2000. 2021 Jun;86(1):201-209. doi: 10.1111/prd.12377. Epub 2021 Mar 10.
Recent advances in our understanding of the microbial populations that colonize the human mouth, their acquisition, interdependency, and coevolution with the host, bring a different perspective to the mechanisms underpinning the maintenance of periodontal health and the development of disease. In this work we suggest that our knowledge map of the etiology of periodontal health and disease can be viewed as a broad, highly connected, and integrated system that spans the entire spectrum of microbe/host/clinical interactions. The overall concept of present Periodontology 2000, that the microbial biofilm can be considered a human tissue of bacteriological origin, is entirely consistent with this integrated system view. The health-associated community structure of microbial biofilms can be considered a system that is normally resilient to perturbation. Equally, there is evidence to suggest that the dysbiotic community structure in disease may share similar resilience properties. In both instances, the resilience may be governed by the precise makeup of the acquired microbiome and by the genetics of the host. Understanding the mechanisms that enable the resistance to change of healthy and dysbiotic microbial populations may be important in the development of approaches to prevent the progression of disease and to restore health in diseased individuals.
最近，我们对定植于人类口腔的微生物种群的认识取得了一些进展，这些微生物种群的获得、相互依存和与宿主的共同进化为维持牙周健康和疾病发展的机制提供了一个不同的视角。在这项工作中，我们认为，我们对牙周健康和疾病病因的知识图谱可以被视为一个广泛的、高度连接和整合的系统，涵盖了微生物/宿主/临床相互作用的整个范围。目前牙周病学 2000 年的总体概念，即微生物生物膜可以被认为是一种具有细菌起源的人类组织，与这个整合系统的观点完全一致。与健康相关的微生物生物膜群落结构可以被认为是一个通常对干扰具有弹性的系统。同样，有证据表明，疾病中的失调群落结构可能具有类似的弹性特性。在这两种情况下，弹性可能受到获得的微生物组的精确组成和宿主的遗传因素的控制。了解使健康和失调的微生物群体能够抵抗变化的机制，对于开发预防疾病进展和恢复患病个体健康的方法可能很重要。
