Hu Jingchao, Zhao Li, Liu Xu, Xu Ling, Zhao Han
Department of Periodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Fan Jia Cun Road 9, Beijing, 100071, China.
Department of Prosthodontics, Stomatological Hospital, Chongqing Medical University, Chongqing, 400015, China.
Saudi Dent J. 2025 Jun 4;37(4-6):15. doi: 10.1007/s44445-025-00023-0.
The aim of this bibliometric analysis was to evaluate research interest and trends in the field of periodontal regeneration from 2000 to 2023. An online search was conducted in the Web of Science Core Collection database to retrieve relevant studies published between 2000 and 2023. Statistical analysis and scientific mapping were performed using R language, CiteSpace, and VOSviewer to examine journals, countries, institutions, authors, keywords, and citations. From 2000 to 2023, a total of 1,932 papers were published, and the number of papers and citations showed consistent growth. The Journal of Periodontology had the highest number of publications and citations. China and the United States were the most productive countries, while contributions from developing nations in Asia and Africa, as well as several Chinese dental institutions, increased significantly. Sculean A was the most prolific author and established a global collaboration network. Seventy-seven high-frequency keywords were identified, with recent trends highlighting 3D printing, hydrogels, and electrospinning. Among the top 25 papers with the strongest citation bursts, eight focused on stem cells and six on enamel matrix derivatives (EMD)/enamel matrix proteins (EMPs), ranking first and second, respectively. Additionally, 15 reference clusters were observed, with melt electrowriting (#0), tissue engineering (#4), exosome (#5), and periodontitis (#7) gaining prominence since 2013, indicating sustained research interest. Periodontal regeneration has remained a prominent research topic. China and the United States are the leading contributors, while developing countries in Asia and Africa have played an increasingly important role in recent years. Research hotspots have evolved dynamically, driven by advancements in biomaterials. Current key themes include hydrogels, 3D printing, electrospinning, melt electrowriting and exosomes; however, clinical evidence supporting these techniques remains limited.
本文献计量分析的目的是评估2000年至2023年牙周再生领域的研究兴趣和趋势。在Web of Science核心合集数据库中进行在线检索，以获取2000年至2023年期间发表的相关研究。使用R语言、CiteSpace和VOSviewer进行统计分析和科学绘图，以研究期刊、国家、机构、作者、关键词和引文。2000年至2023年期间，共发表了1932篇论文，论文数量和引文数量呈持续增长趋势。《牙周病学杂志》的出版物和引文数量最多。中国和美国是产出最多的国家，而亚洲和非洲的发展中国家以及一些中国牙科机构的贡献显著增加。斯库利安·A是产量最高的作者，并建立了一个全球合作网络。确定了77个高频关键词，近期趋势突出了3D打印、水凝胶和电纺丝。在引用爆发最强的前25篇论文中，8篇关注干细胞，6篇关注釉基质衍生物（EMD）/釉基质蛋白（EMP），分别排名第一和第二。此外，观察到15个参考文献聚类，自2013年以来，熔体静电纺丝（#0）、组织工程（#4）、外泌体（#5）和牙周炎（#7）变得突出，表明研究兴趣持续存在。牙周再生一直是一个突出的研究课题。中国和美国是主要贡献者，而亚洲和非洲的发展中国家近年来发挥了越来越重要的作用。研究热点在生物材料进步的推动下动态演变。当前的关键主题包括水凝胶、3D打印、电纺丝、熔体静电纺丝和外泌体；然而，支持这些技术的临床证据仍然有限。
