Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Adv Healthc Mater. 2021 May;10(9):e2002249. doi: 10.1002/adhm.202002249. Epub 2021 Mar 9.
Stratagems of drug delivery are important for disease treatment and other biomedical areas. In this study, a novel stratagem is presented for versatile and controllable drug delivery by integrating photoresponsive drug delivery microspheres (PDDMs) into pyramid microneedle (MN) arrays. The PDDMs, containing black-phosphorus (BP) and poly (N-isopropylacrylamide) (pNIPAM), are generated by a flexible capillary microfluidic method. Benefiting from the high water content of the pNIPAM hydrogel, various bioactive substances can be loaded and maintain biological activity. Furthermore, due to the near-infrared (NIR) absorption and conversion capabilities of the contained BP, the PDDMs can increase temperature, shrink volume, and release their encapsulated bioactives under the trigger of biocompatible NIR. In addition, as the PDDMs are stuffed into the solid MN arrays of porous ethoxylated trimethylolpropane triacrylate (ETPTA), the composited PDDMs-MNs system has enough mechanical strength to penetrate into the skin and can deliver drugs underneath the skin uniformly. Based on the resultant PDDMs-MNs, it is demonstrated that insulin can be controllably released to adjust blood glucose levels of streptozotocin (STZ)-induced diabetic mice. Thus, it is believed that the PDDMs-MNs can act as an excellent drugs delivery system and will find many practical values in clinical medicine.
递药策略对于疾病治疗和其他生物医学领域非常重要。在本研究中，通过将光响应药物输送微球（PDDM）整合到金字塔形微针（MN）阵列中，提出了一种新的策略，用于多功能和可控的药物输送。PDDM 由柔性毛细管微流控方法生成，含有黑磷（BP）和聚（N-异丙基丙烯酰胺）（pNIPAM）。由于 pNIPAM 水凝胶的高含水量，可以装载各种生物活性物质并保持其生物活性。此外，由于所包含的 BP 的近红外（NIR）吸收和转换能力，PDDM 可以在生物相容性 NIR 的触发下升高温度、缩小体积并释放其包裹的生物活性物质。此外，由于 PDDM 被填充到多孔乙氧基化三羟甲基丙烷三丙烯酸酯（ETPTA）的固体 MN 阵列中，复合的 PDDM-MN 系统具有足够的机械强度可以穿透皮肤，并在皮肤下均匀地输送药物。基于所得的 PDDM-MN，证明胰岛素可以被控制释放以调节链脲佐菌素（STZ）诱导的糖尿病小鼠的血糖水平。因此，相信 PDDM-MN 可以作为一种优秀的药物输送系统，并在临床医学中找到许多实际价值。
