van Rossum Huub H, Bietenbeck Andreas, Cervinski Mark A, Katayev Alex, Loh Tze Ping, Badrick Tony C
The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Huvaros, The Netherlands.
Clin Chem Lab Med. 2021 Mar 10. doi: 10.1515/cclm-2021-0072.
In recent years, there has been renewed interest in the "old" average of normals concept, now generally referred to as moving average quality control (MA QC) or patient-based real-time quality control (PBRTQC). However, there are some controversies regarding PBRTQC which this review aims to address while also indicating the current status of PBRTQC.
This review gives the background of certain newly described optimization and validation methods. It also indicates how QC plans incorporating PBRTQC can be designed for greater effectiveness and/or (cost) efficiency. Furthermore, it discusses controversies regarding the complexity of obtaining PBRTQC settings, the replacement of iQC, and software functionality requirements. Finally, it presents evidence of the added value and practicability of PBRTQC.
Recent developments in, and availability of, simulation methods to optimize and validate laboratory-specific PBRTQC procedures have enabled medical laboratories to implement PBRTQC in their daily practice. Furthermore, these methods have made it possible to demonstrate the practicability and added value of PBRTQC by means of two prospective "clinical" studies and other investigations. Although internal QC will remain an essential part of any QC plan, applying PBRTQC can now significantly improve its performance and (cost) efficiency.
近年来，人们对“旧”的正常均值概念重新产生了兴趣，现在通常称为移动平均质量控制（MA QC）或基于患者的实时质量控制（PBRTQC）。然而，关于PBRTQC存在一些争议，本综述旨在解决这些争议，同时说明PBRTQC的现状。
本综述介绍了某些新描述的优化和验证方法的背景。它还指出了如何设计包含PBRTQC的质量控制计划，以提高有效性和/或（成本）效率。此外，它讨论了有关获取PBRTQC设置的复杂性、替代室内质量控制（iQC）以及软件功能要求的争议。最后，它展示了PBRTQC的附加值和实用性的证据。
用于优化和验证特定实验室PBRTQC程序的模拟方法的最新发展和可用性，使医学实验室能够在日常实践中实施PBRTQC。此外，这些方法通过两项前瞻性“临床”研究和其他调查，证明了PBRTQC的实用性和附加值。尽管内部质量控制仍将是任何质量控制计划的重要组成部分，但应用PBRTQC现在可以显著提高其性能和（成本）效率。
