Department of Thoracic Surgery, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, Hangzhou, China.
The Greehey Children's Cancer Research Institute, the University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Cell Cycle. 2021 Apr;20(8):742-751. doi: 10.1080/15384101.2021.1897271. Epub 2021 Mar 10.
Accurate and complete DNA replication and separation are essential for genetic information inheritance and organism maintenance. Errors in DNA duplication are the main source of genetic instability. Understanding DNA duplication regulation is the key to elucidate the mechanisms and find treatment strategies for human genetic disorders, especially cancer. The mechanistic target of rapamycin (mTOR) is a central regulator of cell growth and proliferation by integrating and processing extracellular and intracellular signals to monitor the well-being of cell physiology. mTOR signaling dysregulation is associated with many human diseases including cancer and diabetes. Emerging evidence has demonstrated that mTOR signaling plays a key role in DNA duplication. We herein review the current knowledge of mTOR signaling in the regulation of DNA replication origin licensing, replication fork progression, and stabilization.
准确和完整的 DNA 复制和分离对于遗传信息的传递和生物的维持至关重要。DNA 复制错误是遗传不稳定性的主要来源。了解 DNA 复制的调控是阐明人类遗传疾病（尤其是癌症）机制和寻找治疗策略的关键。雷帕霉素靶蛋白（mTOR）是细胞生长和增殖的核心调节剂，它通过整合和处理细胞内外信号来监测细胞生理学的健康状况。mTOR 信号转导失调与许多人类疾病有关，包括癌症和糖尿病。新出现的证据表明，mTOR 信号在 DNA 复制起始许可、复制叉推进和稳定化的调控中起着关键作用。本文综述了 mTOR 信号在调控 DNA 复制起始点许可、复制叉推进和稳定化中的作用。
