Liu J, Sun L L, He L P, Ling W H, Liu Z M, Chen Y M
Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, People's Republic of China.
Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, People's Republic of China; Guangzhou Panyu Central Hospital, People's Republic of China.
Nutr Metab Cardiovasc Dis. 2014 Oct;24(10):1097-104. doi: 10.1016/j.numecd.2014.04.016. Epub 2014 May 16.
The associations between soy food consumption, cardiometabolic disturbances and subclinical atherosclerosis remain controversial due to limited evidence. We examined the associations of habitual soy food consumption with cardiometabolic disturbances and carotid intima-media thickness (CIMT).
We included 2939 subjects (2135 women and 804 men) aged 50-75 years in this community-based cross-sectional study. Dietary data and other covariates were collected using interviewer-administered questionnaires. We determined CIMT in relation to each subject's common carotid artery, internal carotid artery, carotid bifurcation, blood lipids, glucose and urine acid, blood pressure and waist circumference. A logistic regression model was applied to estimate the odd ratios (ORs) and 95% confidence intervals (CIs), and linear regression was used to estimate the regression coefficient and 95% CIs. After adjusting for potential confounders, we found that greater consumption of soy protein (6.1 vs. 0.5 g/d) was inverse associated with the presence of elevated total cholesterol (TC), dyslipidemia, abdominal obesity and hyperuricemia in women, and with abdominal obesity in men, although no significant sex-soy interactions were observed (P: 0.145-0.985). The consumption of soy protein and isoflavones was inversely associated with the number of cardiometabolic disturbances among women, but not men. There were no significant associations of soy protein and isoflavones with CIMT thickening and other cardiometabolic disturbances.
Greater soy consumption was associated with a lower presence of elevated TC, dyslipidemia, hyperuricemia and less number of cardiometabolic disturbances components in women.
由于证据有限，大豆食品消费、心脏代谢紊乱与亚临床动脉粥样硬化之间的关联仍存在争议。我们研究了习惯性大豆食品消费与心脏代谢紊乱及颈动脉内膜中层厚度（CIMT）之间的关联。
在这项基于社区的横断面研究中，我们纳入了2939名年龄在50 - 75岁之间的受试者（2135名女性和804名男性）。通过访员管理的问卷收集饮食数据和其他协变量。我们测定了与每个受试者的颈总动脉、颈内动脉、颈动脉分叉处相关的CIMT，以及血脂、血糖、尿酸、血压和腰围。应用逻辑回归模型估计比值比（OR）和95%置信区间（CI），并使用线性回归估计回归系数和95% CI。在调整潜在混杂因素后，我们发现大豆蛋白摄入量较高（6.1克/天 vs. 0.5克/天）与女性总胆固醇（TC）升高、血脂异常、腹型肥胖和高尿酸血症的存在呈负相关，与男性腹型肥胖呈负相关，尽管未观察到显著的性别 - 大豆交互作用（P：0.145 - 0.985）。大豆蛋白和异黄酮的消费与女性心脏代谢紊乱的数量呈负相关，但与男性无关。大豆蛋白和异黄酮与CIMT增厚及其他心脏代谢紊乱无显著关联。
大豆摄入量较高与女性TC升高、血脂异常、高尿酸血症的发生率较低以及心脏代谢紊乱成分数量较少相关。
