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先天性心脏病对儿童咳嗽变异性哮喘复发的影响。

Effect of congenital heart disease on the recurrence of cough variant asthma in children.

机构信息

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.

Department of Neonatology of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

出版信息

BMC Cardiovasc Disord. 2021 Mar 10;21(1):130. doi: 10.1186/s12872-021-01940-8.

DOI:10.1186/s12872-021-01940-8
PMID:33691639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7949247/
Abstract

BACKGROUND

The research into the recurrence of cough variant asthma (CVA) in congenital heart disease (CHD) are few in number. The purpose of this study is to investigate the effect of CHD on the risk of the recurrence of CVA.

METHODS

This study was a retrospective cohort study of 489 children with CVA aged between one and 14 years, of whom 67 had CHD complicated with CVA and 134 had CVA without CHD at a ratio of 1:2 according to age, sex and index year. The adjusted hazard ratio (aHR) of CVA recurrence in both the CHD cohort and the non-CHD cohort was determined by multivariate analysis using the Cox proportional hazard regression model.

RESULTS

Adjusting for CHD classification, Mycoplasma pneumonia (MP) infection and immunoglobulin E (IgE) sensitization, the recurrence hazard of CVA in the complex congenital heart disease (CCHD) group (aHR = 3.281; 95% CI 1.648-6.530; P < 0.01) was significantly higher than that in the simple congenital heart disease group (aHR = 2.555; 95% CI 1.739-3.752; P < 0.01). Further, children with IgE sensitization (aHR = 2.172; 95% CI 1.482-3.184; P < 0.01) had a higher recurrence hazard of CVA than those without IgE sensitization, and children with MP infection (aHR = 1.777; 95% CI 1.188-2.657; P < 0.01) had a higher recurrence hazard of CVA than those without the MP infection.

CONCLUSION

The hazard of recurrent CVA is higher in children with CHD, especially in the CCHD children. In addition, those children with IgE sensitization or a MP infection had an increased hazard of recurrent CVA.

摘要

背景

关于先天性心脏病（CHD）并发咳嗽变异性哮喘（CVA）复发的研究较少。本研究旨在探讨 CHD 对 CVA 复发风险的影响。

方法

这是一项回顾性队列研究，纳入了 489 名年龄在 1 至 14 岁之间的 CVA 患儿，其中 67 例 CHD 合并 CVA，134 例 CVA 无 CHD，按年龄、性别和指数年份比例为 1:2。采用 Cox 比例风险回归模型的多因素分析确定 CHD 组和非 CHD 组的 CVA 复发的调整后危险比（aHR）。

结果

在校正 CHD 分类、肺炎支原体（MP）感染和免疫球蛋白 E（IgE）致敏后，复杂先天性心脏病（CCHD）组的 CVA 复发危险比（aHR=3.281；95%CI 1.648-6.530；P<0.01）明显高于单纯性先天性心脏病组（aHR=2.555；95%CI 1.739-3.752；P<0.01）。此外，IgE 致敏（aHR=2.172；95%CI 1.482-3.184；P<0.01）的患儿 CVA 复发危险比高于非 IgE 致敏患儿，而 MP 感染（aHR=1.777；95%CI 1.188-2.657；P<0.01）的患儿 CVA 复发危险比高于非 MP 感染患儿。

结论

CHD 患儿 CVA 复发的风险更高，尤其是 CCHD 患儿。此外，IgE 致敏或 MP 感染的患儿 CVA 复发的风险增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/105fb1cb042c/12872_2021_1940_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/e207abbb21bd/12872_2021_1940_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/afd49a978d67/12872_2021_1940_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/18c26f85cf1d/12872_2021_1940_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/0d33f9f7aeb9/12872_2021_1940_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/105fb1cb042c/12872_2021_1940_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/e207abbb21bd/12872_2021_1940_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/afd49a978d67/12872_2021_1940_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/18c26f85cf1d/12872_2021_1940_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/0d33f9f7aeb9/12872_2021_1940_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f9/7949247/105fb1cb042c/12872_2021_1940_Fig5_HTML.jpg

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