Sung Myongsoon, Kim Ju Hee, Ha Eun Kyo, Shin Jeewon, Kwak Ji Hee, Jee Hye Mi, Han Man Yong
Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, Republic of Korea.
Department of Pediatrics, National Jewish Health, Denver, CO, USA.
Sci Rep. 2024 Apr 23;14(1):9307. doi: 10.1038/s41598-024-59510-9.
The cohort consisted of 9400 exposed children diagnosed with ventricular septal defect (VSD). The risk of community-acquired pneumonia (CAP) or asthma with VSD was assessed using the Cox proportional hazard model with an inverse probability of treatment weighting. During a mean follow-up of 6.67 years (starting from 12 months after birth), there were 2100 CAP admission cases among exposed patients (incidence rate: 33.2 per 1000 person-years) and 20,109 CAP admission cases among unexposed children (incidence rate: 29.6 per 1000 person-years), with hazard ration of 1.09 (95% CI 1.04-1.14).
该队列由9400名被诊断患有室间隔缺损（VSD）的暴露儿童组成。采用治疗权重逆概率的Cox比例风险模型评估VSD儿童发生社区获得性肺炎（CAP）或哮喘的风险。在平均6.67年的随访期间（从出生后12个月开始），暴露患者中有2100例CAP入院病例（发病率：每1000人年33.2例），未暴露儿童中有20109例CAP入院病例（发病率：每1000人年29.6例），风险比为1.09（95%CI 1.04 - 1.14）。
