Department of Paediatrics, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, 311200, Zhejiang, China.
Department of Paediatrics, Zhejiang Xiaoshan Hospital, Hangzhou, 311200, Zhejiang, China.
Adv Rheumatol. 2021 Mar 10;61(1):16. doi: 10.1186/s42358-021-00174-8.
It is important to improve our understanding of the roles of calcium and vitamin D in bone health for preventing osteoporosis. We aimed at exploring the associations between serum calcium, vitamin D level, and bone mineral density (BMD) in adolescents included in the National Health and Nutrition Examination Survey (NHANES) 2001-2006.
Weighted multivariate linear regression models were used to estimate the associations of serum calcium, 25(OH)D level with total BMD. Smooth curve fitting was used to explore the potential non-linear relationship.
A total of 5990 individuals aged between 12 and 19 years were included in this study. The fully-adjusted model showed serum calcium positively correlated with total BMD. However, an inverted U-shaped relationship was found when we performed the smooth curve fitting method, and the inflection point was calculated at 9.6 mg/dL using the two-piecewise linear regression model. In contrast, there was a positive correlation between serum 25(OH)D and total BMD after adjusting for potential confounders.
The present study revealed a positive correlation between serum 25(OH)D level and total BMD, and an inverted U-shaped relationship between serum calcium and total BMD.
为了预防骨质疏松症，深入了解钙和维生素 D 在骨骼健康中的作用非常重要。本研究旨在探讨纳入 2001-2006 年全国健康和营养调查（NHANES）的青少年血清钙、维生素 D 水平与骨密度（BMD）之间的关系。
采用加权多元线性回归模型估计血清钙、25（OH）D 水平与总 BMD 的关系。采用平滑曲线拟合来探索潜在的非线性关系。
本研究共纳入 5990 名 12-19 岁的个体。完全调整模型显示血清钙与总 BMD 呈正相关。然而，当我们使用平滑曲线拟合方法时，发现了一种倒 U 型关系，并且使用两段线性回归模型计算出拐点为 9.6mg/dL。相比之下，在调整潜在混杂因素后，血清 25（OH）D 与总 BMD 呈正相关。
本研究揭示了血清 25（OH）D 水平与总 BMD 之间呈正相关，血清钙与总 BMD 之间呈倒 U 型关系。
