Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China.
Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 519000, Guangdong, China.
Biol Trace Elem Res. 2024 May;202(5):1928-1936. doi: 10.1007/s12011-023-03808-8. Epub 2023 Aug 22.
The peak bone mass (PBM) in puberty has been proven to be a critical determinant of osteoporosis and brittle fractures in the elderly. Selenium is an essential trace element that could influence bone metabolism in our bodies. However, no study has investigated the impact of selenium status on bone mineral density (BMD) among children and adolescents. This was a cross-section study from National Health and Nutrition Examination Survey (NHANES) in the USA involving participants aged 8-19 years. We conducted multiple linear regression models to assess the relationship between selenium status and BMD among children and adolescents, and then stratified analyses were performed according to genders and races. Smooth curve fits and two-piecewise linear regression models were conducted to explore their nonlinear relationship. A total of 4570 participants (2338 boys and 2232 girls) were included in the present study, with a mean age of 13.57 ± 3.41 years. In the multivariable adjustment model, serum selenium was positively associated with lumbar spine BMD (β = 0.021 95% CI: 0.008, 0.034, P = 0.001). The dose-response analyses indicated a non-linear inverted U-shaped relationship between serum selenium and lumbar spine BMD. Lower and higher selenium concentrations were related to decreased BMD, and the inflection point of serum selenium was 2.60 umol/L. The inverted U-shaped association was also observed in females (inflection point: 2.49 umol/L), males (inflection point: 2.65 umol/L), Non-Hispanic White (inflection point: 2.50 umol/L), Non-Hispanic Black (inflection point: 2.50 umol/L), and other races (Including multi-racial) (inflection point: 2.81 umol/L). Our study first shows a non-linear inversed U-shaped association between selenium status and BMD among children and adolescents. The proper selenium status will benefit bone health in children and adolescents. More research is still required to verify our findings and their potential mechanisms.
青春期的峰值骨量（PBM）已被证明是骨质疏松症和老年人脆性骨折的关键决定因素。硒是一种必需的微量元素，它可以影响我们体内的骨骼代谢。然而，目前还没有研究调查硒状态对儿童和青少年骨密度（BMD）的影响。这是美国国家健康和营养检查调查（NHANES）的一项横断面研究，涉及 8-19 岁的参与者。我们进行了多元线性回归模型来评估儿童和青少年中硒状态与 BMD 之间的关系，然后根据性别和种族进行分层分析。进行了平滑曲线拟合和两段线性回归模型来探索它们的非线性关系。本研究共纳入 4570 名参与者（2338 名男孩和 2232 名女孩），平均年龄为 13.57±3.41 岁。在多变量调整模型中，血清硒与腰椎 BMD 呈正相关（β=0.021，95%CI：0.008，0.034，P=0.001）。剂量反应分析表明，血清硒与腰椎 BMD 之间存在非线性倒 U 型关系。较低和较高的硒浓度与 BMD 降低有关，血清硒的拐点为 2.60 umol/L。这种倒 U 型关联也在女性（拐点：2.49 umol/L）、男性（拐点：2.65 umol/L）、非西班牙裔白人（拐点：2.50 umol/L）、非西班牙裔黑人（拐点：2.50 umol/L）和其他种族（包括多种族）（拐点：2.81 umol/L）中观察到。我们的研究首次表明，儿童和青少年中硒状态与 BMD 之间存在非线性倒 U 型关系。适当的硒状态将有益于儿童和青少年的骨骼健康。还需要更多的研究来验证我们的发现及其潜在机制。
