Department of Otolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Department of Otolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Auris Nasus Larynx. 2021 Oct;48(5):934-941. doi: 10.1016/j.anl.2021.02.015. Epub 2021 Mar 7.
The overnight rostral fluid shift from the lower limbs is one of the causes of obstructive sleep apnea (OSA). Compression stockings (CS) prevent lower limb fluid retention and have been reported to decrease nighttime fluid shift. The aim of this study is to evaluate the effect of CS on fluid shift and the severity of OSA.
A systematic literature search was performed in the PubMed, EMBASE and Cochrane Library databases. The data were analyzed using Comprehensive Meta-Analysis software (Version 3; Biostat, Englewood, NJ). Studies evaluating the effect of CS on the overnight fluid shift and OSA severity were included in the analysis.
A total of 4 studies were included in this meta-analysis. The pooled analysis showed that the apnea-hypopnea index (AHI) of the overall study group was significantly lower after using CS (SMD, -1.08; 95% CI, -1.49 to -0.67). Decreases in the AHI were also observed in the normal fluid status (SMD, -1.05; 95% CI, -1.73 to -0.37) and fluid overload status (SMD, -1.17; 95% CI, -1.76 to -0.58) populations. The overall study group had significant decreases in overnight changes in neck circumference (SMD, -1.05; 95% CI, -2.06 to -0.03) and leg fluid volume (SMD, -1.14; 95% CI, -1.88 to -0.41) after using CS. However, no significant differences in overnight changes in neck circumference and leg fluid volume were observed in normal fluid status patients.
CS may help decrease overnight fluid shift and could be a treatment option for OSA.
下肢夜间的向前流体移位是阻塞性睡眠呼吸暂停（OSA）的原因之一。压缩袜（CS）可防止下肢液体积聚，并已被报道可减少夜间流体移位。本研究旨在评估 CS 对流体移位和 OSA 严重程度的影响。
在 PubMed、EMBASE 和 Cochrane Library 数据库中进行系统文献检索。使用 Comprehensive Meta-Analysis 软件（版本 3；Biostat，Englewood，NJ）分析数据。纳入评估 CS 对夜间流体移位和 OSA 严重程度影响的研究进行分析。
共有 4 项研究纳入本荟萃分析。汇总分析显示，使用 CS 后，总体研究组的呼吸暂停低通气指数（AHI）显著降低（SMD，-1.08；95%CI，-1.49 至-0.67）。在正常体液状态（SMD，-1.05；95%CI，-1.73 至-0.37）和体液过载状态（SMD，-1.17；95%CI，-1.76 至-0.58）人群中，AHI 也有降低。使用 CS 后，总体研究组的夜间颈围变化（SMD，-1.05；95%CI，-2.06 至-0.03）和腿部液体积变化（SMD，-1.14；95%CI，-1.88 至-0.41）有显著降低。然而，在正常体液状态患者中，夜间颈围和腿部液体积变化无显著差异。
CS 可能有助于减少夜间流体移位，可能是 OSA 的一种治疗选择。
