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长链非编码RNA LINC00052在肿瘤中的作用。

Role of the long non-coding RNA LINC00052 in tumors.

作者信息

Xiong Dongmei, Wang Dan, Chen Yanmeng

机构信息

Early Childhood Health Research Innovation Team, Nursing School of Chongqing Medical and Pharmaceutical College, Chongqing 401331, P.R. China.

Clinical Laboratory, The People's Hospital of Rongchang, Chongqing 402460, P.R. China.

出版信息

Oncol Lett. 2021 Apr;21(4):316. doi: 10.3892/ol.2021.12577. Epub 2021 Feb 23.

DOI:10.3892/ol.2021.12577
PMID:33692848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7933760/
Abstract

Long intergenic non-protein coding RNA 52 (LINC00052) is a non-coding RNA with >200 nucleotides in length, which exerts important effects on several physiological and pathological processes of the human body. Recent studies have demonstrated that LINC00052 plays key roles in the tumorigenesis, progression and metastasis of multiple types of human cancer, including hepatocellular carcinoma, breast cancer, colorectal cancer, cervical carcinoma and gastric cancer. However, the associations between LINC00052 and these tumors remain unclear. The present review summarizes the biological functions of LINC00052 during the pathogenic process of certain tumors, and discusses its potential therapeutic targets.

摘要

长链基因间非编码RNA 52（LINC00052）是一种长度超过200个核苷酸的非编码RNA，它对人体的多种生理和病理过程发挥着重要作用。最近的研究表明，LINC00052在多种人类癌症的发生、发展和转移中起关键作用，包括肝细胞癌、乳腺癌、结直肠癌、宫颈癌和胃癌。然而，LINC00052与这些肿瘤之间的关联仍不清楚。本综述总结了LINC00052在某些肿瘤致病过程中的生物学功能，并探讨了其潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/7933760/6588e510e427/ol-21-04-12577-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/7933760/6588e510e427/ol-21-04-12577-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1404/7933760/6588e510e427/ol-21-04-12577-g00.jpg

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Role of the long non-coding RNA LINC00052 in tumors.长链非编码RNA LINC00052在肿瘤中的作用。
Oncol Lett. 2021 Apr;21(4):316. doi: 10.3892/ol.2021.12577. Epub 2021 Feb 23.
2
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本文引用的文献

1
Gastric cancer.胃癌。
Lancet. 2020 Aug 29;396(10251):635-648. doi: 10.1016/S0140-6736(20)31288-5.
2
LncRNA PTCSC3 suppressed cervical carcinoma cell invasion and proliferation via regulating miR-574-5p.长链非编码RNA PTCSC3通过调控miR-574-5p抑制宫颈癌细胞的侵袭和增殖。
Am J Transl Res. 2019 Nov 15;11(11):7186-7194. eCollection 2019.
3
RETRACTED: Long non-coding RNA LINC00052 regulates miR-608/EGFR axis to promote progression of head and neck squamous cell carcinoma.撤回：长非编码 RNA LINC00052 通过调控 miR-608/EGFR 轴促进头颈部鳞状细胞癌进展。
基于综合生物信息学研究鉴定与头颈部鳞状细胞癌预后和免疫相关的新型 ceRNA 网络。
Sci Rep. 2022 Oct 20;12(1):17560. doi: 10.1038/s41598-022-21473-0.
4
Hsa_circ_NOTCH3 regulates ZNF146 through sponge adsorption of miR-875-5p to promote tumorigenesis of hepatocellular carcinoma.人源环状RNA NOTCH3通过海绵吸附miR-875-5p调控锌指蛋白146，以促进肝细胞癌的肿瘤发生。
J Gastrointest Oncol. 2021 Oct;12(5):2388-2402. doi: 10.21037/jgo-21-567.
Exp Mol Pathol. 2019 Dec;111:104321. doi: 10.1016/j.yexmp.2019.104321. Epub 2019 Oct 19.
4
LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc.长链非编码 RNA GLCC1 通过稳定 c-Myc 促进结直肠癌发生和葡萄糖代谢。
Nat Commun. 2019 Aug 2;10(1):3499. doi: 10.1038/s41467-019-11447-8.
5
Changes in the transcriptome profile of breast cancer cells grown as spheroids.乳腺癌细胞球体培养中转录组谱的变化。
Biochem Biophys Res Commun. 2019 Sep 3;516(4):1258-1264. doi: 10.1016/j.bbrc.2019.06.155. Epub 2019 Jul 11.
6
Long noncoding RNA LINC00052 suppressed the proliferation, migration and invasion of glioma cells by upregulating KLF6.长链非编码 RNA LINC00052 通过上调 KLF6 抑制胶质瘤细胞的增殖、迁移和侵袭。
Eur Rev Med Pharmacol Sci. 2019 Jun;23(11):4822-4827. doi: 10.26355/eurrev_201906_18068.
7
LINC00052 inhibits tumor growth, invasion and metastasis by repressing STAT3 in cervical carcinoma.LINC00052通过抑制宫颈癌中的STAT3来抑制肿瘤生长、侵袭和转移。
Eur Rev Med Pharmacol Sci. 2019 Jun;23(11):4673-4679. doi: 10.26355/eurrev_201906_18047.
8
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