Zhang Yuhan, Gu Xinquan, Jiang Fuquan, Sun Pinghui, Li Xu
Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
School of Public Health, Jilin University, Changchun, Jilin 130015, P.R. China.
Oncol Lett. 2021 Apr;21(4):331. doi: 10.3892/ol.2021.12592. Epub 2021 Feb 25.
Striatin-4 (STRN4 or Zinedin) is a scaffolding protein belonging to the mammalian STRN family of proteins and consists of multiple functional signaling domains. Due to its numerous signaling complexes, STRN4 has been reported to be involved in the tumorigenesis of various cancer types, including colon cancer, liver cancer and prostate cancer. However, few studies on STRN4 have been conducted in bladder cancer, and its prognostic role in bladder cancer remains unknown. The present study aimed to investigate the expression levels of STRN4 in bladder transitional cell carcinoma and evaluate the prognostic role of STRN4. STRN4 expression in clinical specimens was analyzed using immunohistochemistry and reverse transcription-quantitative PCR. It was demonstrated that STRN4 expression was significantly associated with clinical parameters such as tumor size, muscle invasion depth and pathological tumor grade. Abnormal STRN4 expression was typically associated with worse overall survival time and outcome when compared with the low STRN4 expression group. Using multivariate analysis, it was reported that STRN4 was an independent prognostic biomarker for survival time in bladder transitional cell carcinoma. Although the specific biological mechanisms of STRN4 in bladder cancer still remain to be elucidated, STRN4 expression could be a prognostic indicator in bladder cancer.
条纹蛋白4（STRN4或Zinedin）是一种属于哺乳动物STRN蛋白家族的支架蛋白，由多个功能性信号结构域组成。由于其众多的信号复合物，据报道STRN4参与了包括结肠癌、肝癌和前列腺癌在内的多种癌症类型的肿瘤发生。然而，关于STRN4在膀胱癌中的研究很少，其在膀胱癌中的预后作用仍然未知。本研究旨在调查STRN4在膀胱移行细胞癌中的表达水平，并评估STRN4的预后作用。采用免疫组织化学和逆转录定量PCR分析临床标本中STRN4的表达。结果表明，STRN4表达与肿瘤大小、肌肉浸润深度和病理肿瘤分级等临床参数显著相关。与低STRN4表达组相比，异常STRN4表达通常与较差的总生存时间和预后相关。通过多变量分析，据报道STRN4是膀胱移行细胞癌生存时间的独立预后生物标志物。尽管STRN4在膀胱癌中的具体生物学机制仍有待阐明，但STRN4表达可能是膀胱癌的一个预后指标。
